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Complete genome sequence of a methicillin-resistant Staphylococcus lugdunensis strain and characteristics of its staphylococcal cassette chromosome mec

Shibuya, Rie ; Uehara, Yuki ; Baba, Tadashi ; Teruya, Kuniko ; Satou, Kazuhito ; Hirano, Takashi ; Kirikae, Teruo ; Hiramatsu, Keiichi

Scientific reports, 2020-05, Vol.10 (1), p.8682-8682, Article 8682 [Periódico revisado por pares]

England: Nature Publishing Group

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  • Título:
    Complete genome sequence of a methicillin-resistant Staphylococcus lugdunensis strain and characteristics of its staphylococcal cassette chromosome mec
  • Autor: Shibuya, Rie ; Uehara, Yuki ; Baba, Tadashi ; Teruya, Kuniko ; Satou, Kazuhito ; Hirano, Takashi ; Kirikae, Teruo ; Hiramatsu, Keiichi
  • Assuntos: Bacteremia ; Drug resistance ; Endocarditis ; Genomes ; Infectious diseases ; Methicillin ; Nucleotide sequence ; Penicillin ; Replication origins ; Skin diseases ; Staphylococcus ; Virulence factors ; Whole genome sequencing
  • É parte de: Scientific reports, 2020-05, Vol.10 (1), p.8682-8682, Article 8682
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Symptoms of Staphylococcus lugdunensis infection are often similar to those of Staphylococcus aureus infection, including skin and soft-tissue lesions, bacteremia and infective endocarditis. Despite the severity of these infections, S. lugdunensis is regarded as a less important pathogen than drug-resistant S. aureus. To investigate its ability to cause infectious diseases, a methicillin-resistant S. lugdunensis (MRSL) strain JICS135 was isolated from a patient with bacteremia and subjected to whole genome sequencing. Similar to most strains of methicillin-resistant S. aureus (MRSA), this MRSL strain possessed the staphylococcal cassette chromosome mec (SCCmec) located close to the origin of replication. However, the SCCmec in this MRSL strain, with three ccr complexes, was structurally unique and currently untypable. Moreover, the SCCmec of this MRSL strain was found to carry two genes encoding microbial surface components recognizing adhesive matrix molecules (MSCRAMM)-like proteins accompanied by glycosyl transferases, one of which may have been derived from S. aureus and the other from S. epidermidis, indicating that this MRSL evolved to carry virulence factors from other staphylococci. The emergence of this strain, the first MRSL strain whose genome has been sequenced completely, may be of public concern.
  • Editor: England: Nature Publishing Group
  • Idioma: Inglês
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