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Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations

Costa, Rafael Fernades ; Turones, Larissa Córdova ; Cavalcante, Keilah Valéria Naves ; Rosa Júnior, Ismael Aureliano ; Xavier, Carlos Henrique ; Rosseto, Lucimar Pinheiro ; Napolitano, Hamilton Barbosa ; Castro, Patrícia Ferreira da Silva ; Neto, Marcos Luiz Ferreira ; Galvão, Gustavo Mota ; Menegatti, Ricardo ; Pedrino, Gustavo Rodrigues ; Costa, Elson Alves ; Martins, José Luis Rodrigues ; Fajemiroye, James Oluwagbamigbe

Frontiers in pharmacology, 2021-05, Vol.12, p.666725-666725 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

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Título:
Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations
Autor: Costa, Rafael Fernades ; Turones, Larissa Córdova ; Cavalcante, Keilah Valéria Naves ; Rosa Júnior, Ismael Aureliano ; Xavier, Carlos Henrique ; Rosseto, Lucimar Pinheiro ; Napolitano, Hamilton Barbosa ; Castro, Patrícia Ferreira da Silva ; Neto, Marcos Luiz Ferreira ; Galvão, Gustavo Mota ; Menegatti, Ricardo ; Pedrino, Gustavo Rodrigues ; Costa, Elson Alves ; Martins, José Luis Rodrigues ; Fajemiroye, James Oluwagbamigbe
Assuntos: activities ; derivatives ; functional groups ; heterocyclic ring ; interactions ; Pharmacology
É parte de: Frontiers in pharmacology, 2021-05, Vol.12, p.666725-666725
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Edited by: Syed Nasir Abbas Bukhari, Al Jouf University, Saudi Arabia
Reviewed by: Satyendra Mishra, Institute of Advanced Research (IAR), India
These authors have contributed equally to this work and share first authorship
This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology
Pierfausto Seneci, Institute of Advanced Research (IAR), India
Descrição: Low quality of life and life-threatening conditions often demand pharmacological screening of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole analogs. The substitution, replacement, or removal of functional groups on a pyrazole ring appears consistent with diverse molecular interactions, efficacy, and potency of these analogs. This mini-review explores cytotoxic, cytoprotective, antinociceptive, anti-inflammatory, and antidepressant activities of some pyrazole analogs to advance structure-related pharmacological profiles and rational design of new analogs. Numerous interactions of these derivatives at their targets could impact future research considerations and prospects while offering opportunities for optimizing therapeutic activity with fewer adverse effects.
Editor: Switzerland: Frontiers Media S.A
Idioma: Inglês

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Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations

Switzerland: Frontiers Media S.A

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