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Mild hyperuricemia induces glomerular hypertension in normal rats

Sanchez-Lozada, Laura G ; Tapia, Edilia ; Avila-Casado, Carmen ; Soto, Virgilia ; Franco, Martha ; Santamaria, Jose ; Nakagawa, Takahiko ; Rodriguez-Iturbe, Bernardo ; Johnson, Richard J ; Herrera-Acosta, Jaime

American journal of physiology. Renal physiology, 2002-11, Vol.283 (5), p.1105-F1110 [Periódico revisado por pares]

United States

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Título:
Mild hyperuricemia induces glomerular hypertension in normal rats
Autor: Sanchez-Lozada, Laura G ; Tapia, Edilia ; Avila-Casado, Carmen ; Soto, Virgilia ; Franco, Martha ; Santamaria, Jose ; Nakagawa, Takahiko ; Rodriguez-Iturbe, Bernardo ; Johnson, Richard J ; Herrera-Acosta, Jaime
Assuntos: Animals ; Arterioles - pathology ; Blood Pressure ; Disease Models, Animal ; Hypertension, Renal - chemically induced ; Hypertension, Renal - etiology ; Hypertension, Renal - pathology ; Hypertrophy ; Kidney Glomerulus - blood supply ; Male ; Oxonic Acid ; Rats ; Rats, Sprague-Dawley ; Renal Circulation - physiology ; Uric Acid - blood
É parte de: American journal of physiology. Renal physiology, 2002-11, Vol.283 (5), p.1105-F1110
Descrição: Departments of 1 Nephrology and 2 Pathology, Instituto Nacional de Cardiologia I Chavez, 14080 Mexico City, Mexico; 3 Division of Nephrology, Baylor College of Medicine, Houston, Texas 77030; and 4 Hospital Universitario and Universidad del Zulia, Maracaibo, Venezuela Mildly hyperuricemic rats develop renin-dependent hypertension and interstitial renal disease. Hyperuricemia might also induce changes in glomerular hemodynamics. Micropuncture experiments under deep anesthesia were performed in Sprague-Dawley rats fed a low-salt diet (LS group), fed a low-salt diet and treated with oxonic acid (OA/LS group), and fed a low-salt diet and treated with oxonic acid + allopurinol (OA/LS/AP group) for 5 wk. The OA/LS group developed hyperuricemia and hypertension compared with the LS group: 3.1 ± 0.2 vs. 1.1 ± 0.2 mg/dl ( P < 0.01) and 143 ± 4 vs. 126 ± 2 mmHg ( P < 0.01). Hyperuricemic rats developed increased glomerular capillary pressure compared with the LS rats: 56.7 ± 1.2 vs. 51.9 ± 1.4 mmHg ( P < 0.05). Pre- and postglomerular resistances were not increased. Histology showed afferent arteriolar thickening with increased -smooth muscle actin staining of the media. Allopurinol prevented hyperuricemia (1.14 ± 0.2 mg/dl), systemic (121.8 ± 2.8 mmHg) and glomerular hypertension (50.1 ± 0.8 mmHg), and arteriolopathy in oxonic acid-treated rats. Linear regression analysis showed that glomerular capillary pressure and arteriolar thickening correlated positively with serum uric acid and systolic blood pressure. Glomerular hypertension may be partially mediated by an abnormal vascular response to systemic hypertension due to arteriolopathy of the afferent arteriole. uric acid; arteriolopathy; renal hemodynamics; micropuncture; hypertension
Editor: United States
Idioma: Inglês

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Mild hyperuricemia induces glomerular hypertension in normal rats

Sanchez-Lozada, Laura G ; Tapia, Edilia ; Avila-Casado, Carmen ; Soto, Virgilia ; Franco, Martha ; Santamaria, Jose ; Nakagawa, Takahiko ; Rodriguez-Iturbe, Bernardo ; Johnson, Richard J ; Herrera-Acosta, Jaime

United States

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