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Marine-Derived Penicillium Species as Producers of Cytotoxic Metabolites

Liu, Sen ; Su, Mingzhi ; Song, Shao-Jiang ; Jung, Jee H

Marine drugs, 2017-10, Vol.15 (10), p.329 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Marine-Derived Penicillium Species as Producers of Cytotoxic Metabolites
Autor: Liu, Sen ; Su, Mingzhi ; Song, Shao-Jiang ; Jung, Jee H
Assuntos: Alkaloids - chemical synthesis ; Alkaloids - isolation & purification ; Alkaloids - pharmacology ; Alkaloids - therapeutic use ; Antineoplastic Agents - chemical synthesis ; Antineoplastic Agents - isolation & purification ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; Aquatic Organisms - metabolism ; Biocompatibility ; Biological Products - chemical synthesis ; Biological Products - isolation & purification ; Biological Products - pharmacology ; Biological Products - therapeutic use ; biosynthesis ; Biotechnology - methods ; cytotoxic metabolites ; Cytotoxicity ; Humans ; Inhibitory Concentration 50 ; Lipopeptides - chemical synthesis ; Lipopeptides - isolation & purification ; Lipopeptides - pharmacology ; Lipopeptides - therapeutic use ; marine-derived Penicillium ; Metabolites ; Mortality causes ; natural products ; Neoplasms - drug therapy ; Oceans and Seas ; Penicillin ; Penicillium ; Penicillium - metabolism ; Polyketides - chemical synthesis ; Polyketides - isolation & purification ; Polyketides - pharmacology ; Polyketides - therapeutic use ; Review ; Species ; Terpenes - chemical synthesis ; Terpenes - isolation & purification ; Terpenes - pharmacology ; Terpenes - therapeutic use ; Toxicity ; Toxicity tests
É parte de: Marine drugs, 2017-10, Vol.15 (10), p.329
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Since the discovery of penicillin, has become one of the most attractive fungal genera for the production of bioactive molecules. Marine-derived has provided numerous excellent pharmaceutical leads over the past decades. In this review, we focused on the cytotoxic metabolites * (* Cytotoxic potency was referred to five different levels in this review, extraordinary (IC /LD : <1 μM or 0.5 μg/mL); significant (IC /LD : 1~10 μM or 0.5~5 μg/mL); moderate (IC /LD : 10~30 μM or 5~15 μg/mL); mild (IC /LD : 30~50 μM or 15~25 μg/mL); weak (IC /LD : 50~100 μM or 25~50 μg/mL). The comparative potencies of positive controls were referred when they were available). produced by marine-derived species, and on their cytotoxicity mechanisms, biosyntheses, and chemical syntheses.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Marine-Derived Penicillium Species as Producers of Cytotoxic Metabolites

Liu, Sen ; Su, Mingzhi ; Song, Shao-Jiang ; Jung, Jee H

Switzerland: MDPI AG

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