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Colorectal cancer in patients under 50 years of age: a retrospective analysis of two institutions' experience

Myers, Elizabeth A ; Feingold, Daniel L ; Forde, Kenneth A ; Arnell, Tracey ; Jang, Joon Ho ; Whelan, Richard L

World journal of gastroenterology : WJG, 2013-09, Vol.19 (34), p.5651-5657

United States: Baishideng Publishing Group Co., Limited

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  • Título:
    Colorectal cancer in patients under 50 years of age: a retrospective analysis of two institutions' experience
  • Autor: Myers, Elizabeth A ; Feingold, Daniel L ; Forde, Kenneth A ; Arnell, Tracey ; Jang, Joon Ho ; Whelan, Richard L
  • Assuntos: Adolescent ; Adult ; Age of Onset ; Brief ; Carcinoma - epidemiology ; Carcinoma - genetics ; Carcinoma - pathology ; Carcinoma - surgery ; Colon - pathology ; Colorectal Neoplasms - epidemiology ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; New York - epidemiology ; Postoperative Complications - epidemiology ; Retrospective Studies ; Young Adult
  • É parte de: World journal of gastroenterology : WJG, 2013-09, Vol.19 (34), p.5651-5657
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Correspondence to: Richard L Whelan, MD, Department of Colon and Rectal Surgery, St. Luke’s Roosevelt Hospital, 25 West 59th St., Suite 7B, New York, NY 10019, United States. rwhelan@chpnet.org
    Telephone: +1-212-5238172 Fax: +1-212-5238857
    Author contributions: Whelan RL, Feingold DL, Arnell T and Forde KA designed research; Myer EA performed research; Myers EA and Jang JH analyzed data; Myers EA and Whelan RL wrote the paper.
  • Descrição: To investigate the epidemiological characteristics of colorectal cancer (CRC) in patients under 50 years of age across two institutions. Records of patients under age 50 years of age who had CRC surgery over a 16 year period were assessed at two institutions. The following documents where reviewed: admission notes, operative notes, and discharge summaries. The main study variables included: age, presenting symptoms, family history, tumor location, operation, stage/differentiation of disease, and post operative complications. Stage of disease was classified according to the American Joint Committee on Cancer TNM staging system: tumor depth; node status; and metastases. CRC was found in 180 patients under age 50 years (87 females, 93 males; mean age 41.4 ± 6.2 years). Young patients accounted for 11.2% of cases during a 6 year period for which the full data set was available. Eight percent had a 1(st) degree and 12% a 2(nd) degree family CRC history. Almost all patients (94%) were symptomatic at diagnosis; common symptoms included: bleeding (59%), obstruction (9%), and abdominal/rectal pain (35%). Evaluation was often delayed and bleeding frequently attributed to hemorrhoids. Advanced stage CRC (Stage 3 or 4) was noted in 53% of patients. Most tumors were distal to the splenic flexure (77%) and 39% involved the rectum. Most patients (95%) had segmental resections; 6 patients had subtotal/total colectomy. Poorly differentiated tumors were noted in 12% and mucinous lesions in 19% of patients of which most had Stage 3 or 4 disease. Twenty-two patients (13%) developed recurrence and/or progression of disease to date. Three patients (ages 42, 42 and 49 years) went on to develop metachronous primary colon cancers within 3 to 4 years of their initial resection. CRC was common in young patients with no family history. Young patients with symptoms merit a timely evaluation to avoid presentation with late stage CRC.
  • Editor: United States: Baishideng Publishing Group Co., Limited
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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