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Sclerotic bone: a sign of bone reaction in patients with medication related osteonecrosis of the jaw

Obermeier, Katharina Theresa ; Dewenter, Ina ; Malenova, Yoana ; Fliefel, Riham ; Kaeppler, Gabriele ; Otto, Sven

Scientific reports, 2024-04, Vol.14 (1), p.7914-7914, Article 7914 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Sclerotic bone: a sign of bone reaction in patients with medication related osteonecrosis of the jaw
Autor: Obermeier, Katharina Theresa ; Dewenter, Ina ; Malenova, Yoana ; Fliefel, Riham ; Kaeppler, Gabriele ; Otto, Sven
Assuntos: Antiresorptive drugs ; Bisphosphonate-Associated Osteonecrosis of the Jaw ; Bisphosphonate-Associated Osteonecrosis of the Jaw - diagnostic imaging ; Bisphosphonate-Associated Osteonecrosis of the Jaw - drug therapy ; Bisphosphonate-Associated Osteonecrosis of the Jaw - surgery ; Bisphosphonates ; Bone density ; Bone Density Conservation Agents - adverse effects ; Bone mineral density ; Bone necrosis ; Bone regeneration ; Bones ; Correlation ; Denosumab - adverse effects ; Density ; Diphosphonates - adverse effects ; Humans ; Jaw ; Lesions ; Modelling ; Necrosis ; Necrosis - chemically induced ; Osteonecrosis ; Osteonecrosis - chemically induced ; Osteonecrosis - diagnostic imaging ; Osteonecrosis - surgery ; Osteotomy ; Patients ; Radiography ; Retrospective Studies
É parte de: Scientific reports, 2024-04, Vol.14 (1), p.7914-7914, Article 7914
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Medication-related osteonecrosis of the jaw (MRONJ) is a serious adverse reaction associated with antiresorptive drugs such as bisphosphonates and denosumab. When dealing with advanced and/or multiple MRONJ lesions undergoing surgical therapy, the extent of surgery is often a topic of discussion. The aim of this study was to identify the differences in bone density in and around the MRONJ lesion before and after surgical treatment to evaluate the needed surgical extend of the modelling osteotomy. In this retrospective study 26 patients with MRONJ lesions that were surgically treated in our department were observed. Length, width and bone density were measured in panoramic radiograph pre and postoperatively with the Imaging processing software Sidexis and ImageJ (Fiji). The necrotic area, the surrounding sclerotic area as well as the healthy contralateral side were observed. Measurements were performed by two independent observers. Pearson correlation was calculated to determine the interobserver variability. Bone density was significantly reduced in the necrotic bone area compared to the healthy unaffected contralateral reference side. The sclerotic bone area surrounding the necrosis showed increased bone density compared to the contralateral unaffected reference side. The density of the sclerotic bone area was increased in the previously affected MRONJ area in the postoperative panoramic radiograph. The pre and postoperative density showed no significant correlation to healing behaviour. The focus of the modelling osteotomy in surgical treatment of mature MRONJ lesions should be predominantly on the parts that appear necrotic and less dense in the panoramic radiograph as sclerotic areas might be an expression of bone reaction.
Editor: England: Nature Publishing Group
Idioma: Inglês

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