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Shaping Our Minds: Stem and Progenitor Cell Diversity in the Mammalian Neocortex

Franco, Santos J. ; Müller, Ulrich

Neuron (Cambridge, Mass.), 2013-01, Vol.77 (1), p.19-34 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Shaping Our Minds: Stem and Progenitor Cell Diversity in the Mammalian Neocortex
  • Autor: Franco, Santos J. ; Müller, Ulrich
  • Assuntos: Animals ; Brain ; Cell Differentiation - physiology ; Humans ; Medical research ; Neocortex - cytology ; Neocortex - physiology ; Nerve Net - cytology ; Nerve Net - physiology ; Neural Stem Cells - physiology ; Neurogenesis - physiology ; Neurons - physiology ; Psychophysiology ; Rodents ; Schizophrenia ; Stem Cells - physiology ; Studies
  • É parte de: Neuron (Cambridge, Mass.), 2013-01, Vol.77 (1), p.19-34
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
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    ObjectType-Review-1
    ObjectType-Feature-1
  • Descrição: The neural circuits of the mammalian neocortex are crucial for perception, complex thought, cognition, and consciousness. This circuitry is assembled from many different neuronal subtypes with divergent properties and functions. Here, we review recent studies that have begun to clarify the mechanisms of cell-type specification in the neocortex, focusing on the lineage relationships between neocortical progenitors and subclasses of excitatory projection neurons. These studies reveal an unanticipated diversity in the progenitor pool that requires a revised view of prevailing models of cell-type specification in the neocortex. We propose a “sequential progenitor-diversification model” that integrates current knowledge to explain how projection neuron diversity is achieved by mechanisms acting on proliferating progenitors and their postmitotic offspring. We discuss the implications of this model for our understanding of brain evolution and pathological states of the neocortex. The developing neocortex contains progenitor cells in the ventricular neuroepithelium that give rise to many distinct subtypes of excitatory projection neurons. Here, Franco and Müller summarize recent findings that have revealed an unexpected complexity and diversity in this progenitor pool.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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