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Isoflavin‐β modifies muscle oxidative stress and prevents a thyrotoxicosis‐induced loss of muscle mass in rats

Marinello, Poliana C. ; Bernardes, Sara S. ; Guarnier, Flávia A. ; Silva, Thamara N.X. ; Borges, Fernando H. ; Lopes, Natália M.D. ; Simão, Andréa N.C. ; Armani, André ; Cecchini, Rubens ; Cecchini, Alessandra L.

Muscle & nerve, 2017-11, Vol.56 (5), p.975-981 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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Título:
Isoflavin‐β modifies muscle oxidative stress and prevents a thyrotoxicosis‐induced loss of muscle mass in rats
Autor: Marinello, Poliana C. ; Bernardes, Sara S. ; Guarnier, Flávia A. ; Silva, Thamara N.X. ; Borges, Fernando H. ; Lopes, Natália M.D. ; Simão, Andréa N.C. ; Armani, André ; Cecchini, Rubens ; Cecchini, Alessandra L.
Assuntos: Animals ; Antioxidants ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Carbonyls ; Chymotrypsin - metabolism ; Cyclohexanols - blood ; Cyclohexanols - toxicity ; Cytochrome ; Cytochrome-c oxidase ; Disease Models, Animal ; Drug Administration Schedule ; Electron Transport Complex IV - metabolism ; Euthanasia ; Gastrocnemius muscle ; Glycerol - blood ; isoflavin‐β ; Isoflavones ; Isoflavones - pharmacology ; Isoflavones - therapeutic use ; isoflavones; muscle proteolysis ; Lipid peroxidation ; Male ; Mitochondria ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - pathology ; Muscular Atrophy ; Myopathy ; Oxidase ; Oxidation ; Oxidative stress ; Oxidative Stress - drug effects ; Peritoneum ; Peroxidation ; Prevention ; Protein Carbonylation - drug effects ; Proteins ; Proteolysis ; Rats ; Rats, Wistar ; Rodents ; Superoxide Dismutase - metabolism ; tert-Butylhydroperoxide - metabolism ; Thiobarbituric Acid Reactive Substances - metabolism ; Thyrotoxicosis ; Thyrotoxicosis - blood ; Thyrotoxicosis - chemically induced ; Thyrotoxicosis - pathology ; Thyrotoxicosis - prevention & control
É parte de: Muscle & nerve, 2017-11, Vol.56 (5), p.975-981
Descrição: ABSTRACT Introduction We sought to verify whether isoflavin‐beta (Iso‐β), a mixture of isoflavones with antioxidant properties, could prevent thyrotoxicosis‐induced loss of muscle mass and the participation of oxidative stress (OS) in the mechanisms of this prevention. Methods Two experimental periods of thyrotoxicosis induction were used in Wistar rats: 3 and 5 days to assess Iso‐β effects before and after thyrotoxicosis‐induced muscle wasting. After euthanasia, peritoneal fat and gastrocnemius muscle were collected, weighed, and muscle OS was assessed. Results Iso‐β prevented the loss of gastrocnemius mass in thyrotoxic rats through the prevention of muscle OS generation during thyrotoxicosis, increasing muscle total antioxidant capacity and decreasing mitochondrial cytochrome c oxidase activity, lipid peroxidation, and protein carbonyl content. Conclusion Iso‐β decreased oxidative modification of proteins, which is known to exert a major role during proteolysis induction and is present in thyrotoxic myopathy, highlighting the potential action of Iso‐β in this complication of the disease. Muscle Nerve 56: 975–981, 2017
Editor: United States: Wiley Subscription Services, Inc
Idioma: Inglês

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Isoflavin‐β modifies muscle oxidative stress and prevents a thyrotoxicosis‐induced loss of muscle mass in rats

Marinello, Poliana C. ; Bernardes, Sara S. ; Guarnier, Flávia A. ; Silva, Thamara N.X. ; Borges, Fernando H. ; Lopes, Natália M.D. ; Simão, Andréa N.C. ; Armani, André ; Cecchini, Rubens ; Cecchini, Alessandra L.

United States: Wiley Subscription Services, Inc

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