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Comparative Genomics of Gene Loss and Gain in Caenorhabditis and Other Nematodes

Rödelsperger, Christian

Comparative Genomics, 2018-01, Vol.1704, p.419-432

New York, NY: Springer New York

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  • Título:
    Comparative Genomics of Gene Loss and Gain in Caenorhabditis and Other Nematodes
  • Autor: Rödelsperger, Christian
  • Assuntos: Animals ; Biological Evolution ; Caenorhabditis - genetics ; Duplication ; Evolution, Molecular ; Gene Duplication ; Gene Expression Regulation ; Genes, Helminth ; Genome evolution ; Genome, Helminth ; Genomics - methods ; Lateral gene transfer ; Nematoda - genetics ; Orphan genes ; Parasite ; Phylogeny ; Species Specificity
  • É parte de: Comparative Genomics, 2018-01, Vol.1704, p.419-432
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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  • Descrição: Nematodes, such as Caenorhabditis elegans, form one of the most species-rich animal phyla. By now more than 30 nematode genomes have been published allowing for comparative genomic analyses at various different time-scales. The majority of a nematode’s gene repertoire is represented by either duplicated or so-called orphan genes of unknown origin. This indicates the importance of mechanisms that generate new genes during the course of evolution. While it is certain that nematodes have acquired genes by horizontal gene transfer from various donors, this process only explains a small portion of the nematode gene content. As evolutionary genomic analyses strongly support that most orphan genes are indeed protein-coding, future studies will have to decide, whether they are result from extreme divergence or evolved de novo from previously noncoding sequences. In this contribution, I summarize several studies investigating gene loss and gain in nematodes and discuss the strengths and weaknesses of individual approaches and datasets. These approaches can be used to ask nematode-specific questions such as associated with the evolution of parasitism or with switches in mating systems, but also can complement studies in other animal phyla like vertebrates and insects to broaden our general view on genome evolution.
  • Editor: New York, NY: Springer New York
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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