Idioma:

Genomewide association studies of suicide attempts in US soldiers

Stein, Murray B. ; Ware, Erin B. ; Mitchell, Colter ; Chen, Chia‐Yen ; Borja, Susan ; Cai, Tianxi ; Dempsey, Catherine L. ; Fullerton, Carol S. ; Gelernter, Joel ; Heeringa, Steven G. ; Jain, Sonia ; Kessler, Ronald C. ; Naifeh, James A. ; Nock, Matthew K. ; Ripke, Stephan ; Sun, Xiaoying ; Beckham, Jean C. ; Kimbrel, Nathan A. ; Ursano, Robert J ; Smoller, Jordan W.

American journal of medical genetics. Part B, Neuropsychiatric genetics, 2017-12, Vol.174 (8), p.786-797 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Genomewide association studies of suicide attempts in US soldiers
Autor: Stein, Murray B. ; Ware, Erin B. ; Mitchell, Colter ; Chen, Chia‐Yen ; Borja, Susan ; Cai, Tianxi ; Dempsey, Catherine L. ; Fullerton, Carol S. ; Gelernter, Joel ; Heeringa, Steven G. ; Jain, Sonia ; Kessler, Ronald C. ; Naifeh, James A. ; Nock, Matthew K. ; Ripke, Stephan ; Sun, Xiaoying ; Beckham, Jean C. ; Kimbrel, Nathan A. ; Ursano, Robert J ; Smoller, Jordan W.
Assuntos: Adrenal cortex ; Adult ; Bipolar disorder ; Case-Control Studies ; Energy balance ; Female ; Genetic Predisposition to Disease ; Genetics ; Genome-Wide Association Study ; genomewide association ; Genotype ; Health risk assessment ; Homeostasis ; Humans ; Incidence ; Male ; Melanocortin ; military ; Military personnel ; Military Personnel - statistics & numerical data ; Polymorphism, Single Nucleotide ; Public health ; Regression analysis ; Replication ; risk ; Risk Factors ; Single-nucleotide polymorphism ; Suicide ; suicide attempt ; Suicide, Attempted - statistics & numerical data ; Suicides & suicide attempts ; United States ; Young Adult
É parte de: American journal of medical genetics. Part B, Neuropsychiatric genetics, 2017-12, Vol.174 (8), p.786-797
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Suicide is a global public health problem with particular resonance for the US military. Genetic risk factors for suicidality are of interest as indicators of susceptibility and potential targets for intervention. We utilized population‐based nonclinical cohorts of US military personnel (discovery: N = 473 cases and N = 9778 control subjects; replication: N = 135 cases and N = 6879 control subjects) and a clinical case‐control sample of recent suicide attempters (N = 51 cases and N = 112 control subjects) to conduct GWAS of suicide attempts (SA). Genomewide association was evaluated within each ancestral group (European‐, African‐, Latino‐American) and study using logistic regression models. Meta‐analysis of the European ancestry discovery samples revealed a genomewide significant locus in association with SA near MRAP2 (melanocortin 2 receptor accessory protein 2) and CEP162 (centrosomal protein 162); 12 genomewide significant SNPs in the region; peak SNP rs12524136‐T, OR = 2.88, p = 5.24E‐10. These findings were not replicated in the European ancestry subsamples of the replication or suicide attempters samples. However, the association of the peak SNP remained significant in a meta‐analysis of all studies and ancestral subgroups (OR = 2.18, 95%CI 1.70, 2.80). Polygenic risk score (PRS) analyses showed some association of SA with bipolar disorder. The association with SNPs encompassing MRAP2, a gene expressed in brain and adrenal cortex and involved in neural control of energy homeostasis, points to this locus as a plausible susceptibility gene for suicidality that should be further studied. Larger sample sizes will be needed to confirm and extend these findings.
Editor: United States: Wiley Subscription Services, Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Genomewide association studies of suicide attempts in US soldiers

United States: Wiley Subscription Services, Inc

Buscando em bases de dados remotas. Favor aguardar.