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Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus

Huang, I-Chueh ; Bailey, Charles C ; Weyer, Jessica L ; Radoshitzky, Sheli R ; Becker, Michelle M ; Chiang, Jessica J ; Brass, Abraham L ; Ahmed, Asim A ; Chi, Xiaoli ; Dong, Lian ; Longobardi, Lindsay E ; Boltz, Dutch ; Kuhn, Jens H ; Elledge, Stephen J ; Bavari, Sina ; Denison, Mark R ; Choe, Hyeryun ; Farzan, Michael Baric, Ralph S.

PLoS pathogens, 2011-01, Vol.7 (1), p.e1001258-e1001258 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus
Autor: Huang, I-Chueh ; Bailey, Charles C ; Weyer, Jessica L ; Radoshitzky, Sheli R ; Becker, Michelle M ; Chiang, Jessica J ; Brass, Abraham L ; Ahmed, Asim A ; Chi, Xiaoli ; Dong, Lian ; Longobardi, Lindsay E ; Boltz, Dutch ; Kuhn, Jens H ; Elledge, Stephen J ; Bavari, Sina ; Denison, Mark R ; Choe, Hyeryun ; Farzan, Michael
Baric, Ralph S.
Assuntos: Animals ; Antigens, Differentiation - immunology ; Antigens, Differentiation - metabolism ; Cell Line, Tumor ; Cercopithecus aethiops ; Disease transmission ; Ebola virus ; Endothelium, Vascular ; Female ; Filoviridae - growth & development ; Filoviridae - pathogenicity ; Filovirus ; Host-Pathogen Interactions ; Humans ; Influenza ; Influenza A virus ; Influenza A virus - growth & development ; Influenza A virus - pathogenicity ; Interferon ; Marburg virus ; Membrane proteins ; Mice ; Microscopy ; Physiological aspects ; Proteins ; RNA viruses ; SARS coronavirus ; SARS Virus - growth & development ; SARS Virus - pathogenicity ; Vero Cells ; Virology/Host Antiviral Responses ; Virology/Host Invasion and Cell Entry ; Virus Diseases - immunology ; Virus Diseases - metabolism ; Virus Diseases - virology ; Virus Internalization ; Virus Replication ; Viruses
É parte de: PLoS pathogens, 2011-01, Vol.7 (1), p.e1001258-e1001258
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Conceived and designed the experiments: ICH CCB SRR MMB MRD MF. Performed the experiments: ICH CCB JLW MMB JJC AAA XC LD LEL DB. Analyzed the data: ICH CCB SRR MMB JHK SB MRD HC MF. Contributed reagents/materials/analysis tools: SRR ALB SJE SB. Wrote the paper: ICH MF.
Descrição: Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM1, 2, and 3) are recently identified viral restriction factors that inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. Here we show that IFITM proteins restricted infection mediated by the entry glycoproteins (GP(1,2)) of Marburg and Ebola filoviruses (MARV, EBOV). Consistent with these observations, interferon-β specifically restricted filovirus and IAV entry processes. IFITM proteins also inhibited replication of infectious MARV and EBOV. We observed distinct patterns of IFITM-mediated restriction: compared with IAV, the entry processes of MARV and EBOV were less restricted by IFITM3, but more restricted by IFITM1. Moreover, murine Ifitm5 and 6 did not restrict IAV, but efficiently inhibited filovirus entry. We further demonstrate that replication of infectious SARS coronavirus (SARS-CoV) and entry mediated by the SARS-CoV spike (S) protein are restricted by IFITM proteins. The profile of IFITM-mediated restriction of SARS-CoV was more similar to that of filoviruses than to IAV. Trypsin treatment of receptor-associated SARS-CoV pseudovirions, which bypasses their dependence on lysosomal cathepsin L, also bypassed IFITM-mediated restriction. However, IFITM proteins did not reduce cellular cathepsin activity or limit access of virions to acidic intracellular compartments. Our data indicate that IFITM-mediated restriction is localized to a late stage in the endocytic pathway. They further show that IFITM proteins differentially restrict the entry of a broad range of enveloped viruses, and modulate cellular tropism independently of viral receptor expression.
Editor: United States: Public Library of Science
Idioma: Inglês

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Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus

United States: Public Library of Science

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