Idioma:

Low-grade inflammation predicts persistence of depressive symptoms

Zalli, A. ; Jovanova, O. ; Hoogendijk, W. J. G. ; Tiemeier, H. ; Carvalho, L. A.

Psychopharmacology, 2016-05, Vol.233 (9), p.1669-1678 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

Texto completo disponível

Citações Citado por

Enviar para

Título:
Low-grade inflammation predicts persistence of depressive symptoms
Autor: Zalli, A. ; Jovanova, O. ; Hoogendijk, W. J. G. ; Tiemeier, H. ; Carvalho, L. A.
Assuntos: Aged ; Aged, 80 and over ; Aging - psychology ; alpha 1-Antichymotrypsin - metabolism ; Biomarkers - analysis ; Biomarkers - metabolism ; Biomedical and Life Sciences ; Biomedicine ; C-Reactive Protein - metabolism ; Cross-Sectional Studies ; Cytokines ; Cytokines - analysis ; Cytokines - metabolism ; Depression (Mood disorder) ; Depression - metabolism ; Depression - psychology ; Female ; Follow-Up Studies ; Humans ; Immune system ; Inflammation ; Inflammation - metabolism ; Inflammation - psychology ; Interleukin-6 - metabolism ; Longitudinal Studies ; Male ; Mental depression ; Middle Aged ; Neuropsychology ; Neurosciences ; Original Investigation ; Pharmacology/Toxicology ; Physiological aspects ; Psychiatric Status Rating Scales ; Psychiatry
É parte de: Psychopharmacology, 2016-05, Vol.233 (9), p.1669-1678
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Rationale Evidence suggests that depression is cross-sectionally and longitudinally associated with activation of inflammatory response system. A few studies, however, have investigated the longitudinal relationship between raised inflammatory biomarkers and persistence of depressive symptoms. We examined the temporal relationship between serum levels of inflammatory biomarkers and persistence of depressive symptoms among older participants. Methods Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess depressive symptoms at baseline and at 5-year follow-up in 656 participants (233 men, 423 women) aged >60 years of the Rotterdam Study. Markers of inflammation interleukin (IL)-6, alpha-1-antichymotrypsin (ACT) and C-reactive protein (CRP) were assessed at baseline, and all participants taking antidepressant medications were excluded from the analysis. Results No cross-sectional association was found between IL-6, ACT and CRP with depressive symptoms at baseline. However, higher levels of IL-6 and CRP predicted depressive symptoms at 5-year follow-up. Adjustment for confounding variables had no impact on the observed associations. Similarly, a positive association was found between baseline levels of IL-6 (OR = 2.44, p = 0.030) and CRP (OR = 1.81, p = 0.052) and persistence of depressive symptoms over 5 years. Conclusion Our data suggest that dysregulation of the inflammatory response system is associated with a more severe form of depression more likely to re-occur.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 9 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Low-grade inflammation predicts persistence of depressive symptoms

Zalli, A. ; Jovanova, O. ; Hoogendijk, W. J. G. ; Tiemeier, H. ; Carvalho, L. A.

Berlin/Heidelberg: Springer Berlin Heidelberg

Buscando em bases de dados remotas. Favor aguardar.