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Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

SHENG, Zu-Hang ; QIAN CAI

Nature reviews. Neuroscience, 2012-02, Vol.13 (2), p.77-93 [Periódico revisado por pares]

London: Nature Publishing Group

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Título:
Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration
Autor: SHENG, Zu-Hang ; QIAN CAI
Assuntos: Animals ; Biological and medical sciences ; Biological transport ; Biological Transport - physiology ; Calcium - metabolism ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Fundamental and applied biological sciences. Psychology ; General aspects. Models. Methods ; Homeostasis ; Homeostasis - physiology ; Humans ; Medical sciences ; Metabolism ; Mitochondria ; Mitochondria - physiology ; Models, Neurological ; Neurodegeneration ; Neurodegenerative Diseases - etiology ; Neurodegenerative Diseases - pathology ; Neurological disorders ; Neurology ; Neurons ; Neurons - pathology ; Neurons - ultrastructure ; Neurosciences ; Pathogenesis ; Physiological aspects ; Physiology ; Proteins ; Synapses - pathology ; Synapses - physiology ; Vertebrates: nervous system and sense organs
É parte de: Nature reviews. Neuroscience, 2012-02, Vol.13 (2), p.77-93
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Descrição: Mitochondria have a number of essential roles in neuronal function. Their complex mobility patterns within neurons are characterized by frequent changes in direction. Mobile mitochondria can become stationary or pause in regions that have a high metabolic demand and can move again rapidly in response to physiological changes. Defects in mitochondrial transport are implicated in the pathogenesis of several major neurological disorders. Research into the mechanisms that regulate mitochondrial transport is thus an important emerging frontier.
Editor: London: Nature Publishing Group
Idioma: Inglês

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Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

SHENG, Zu-Hang ; QIAN CAI

London: Nature Publishing Group

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