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Corticosteroidogenesis in vitro: effects of parathyroid hormone, ACTH, and calcium

Carsia, R V ; Segre, G V ; Clark, I ; Malamed, S

Experimental biology and medicine (Maywood, N.J.), 1981-07, Vol.167 (3), p.402-406 [Periódico revisado por pares]

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Título:
Corticosteroidogenesis in vitro: effects of parathyroid hormone, ACTH, and calcium
Autor: Carsia, R V ; Segre, G V ; Clark, I ; Malamed, S
Assuntos: Adrenal Cortex - metabolism ; Adrenocorticotropic Hormone - pharmacology ; Animals ; Calcium - pharmacology ; Cells, Cultured ; Corticosterone - biosynthesis ; Drug Synergism ; Male ; Parathyroid Hormone - pharmacology ; Rats
É parte de: Experimental biology and medicine (Maywood, N.J.), 1981-07, Vol.167 (3), p.402-406
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Descrição: Isolated rat adrenocortical cells were incubated with bovine parathyroid hormone (PTH) in the absence and presence of ACTH and CaCl sub(2). PTH had no effect on corticosterone production, but CaCl sub(2) induced steroidogenesis in the absence or presence of ACTH. Maximal corticosterone production in the absence of ACTH occurred with 1.25 mM CaCl sub(2) and in the presence of ACTH with 5.00 mM CaCl sub(2). These results show that PTH does not directly affect acute corticosterone production by isolated adrenocortical cells. They also show that ACTH raises the maximal steroidogenesis inducible by CaCl sub(2).
Editor: United States
Idioma: Inglês

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