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Predictive value of high sensitivity C-reactive protein in patients with ST-elevation myocardial infarction treated with percutaneous coronary intervention

Ortolani, Paolo ; Marzocchi, Antonio ; Marrozzini, Cinzia ; Palmerini, Tullio ; Saia, Francesco ; Taglieri, Nevio ; Baldazzi, Federica ; Silenzi, Simona ; Bacchi-Reggiani, Maria Letizia ; Guastaroba, Paolo ; Grilli, Roberto ; Branzi, Angelo

European heart journal, 2008-05, Vol.29 (10), p.1241-1249 [Periódico revisado por pares]

Oxford: Oxford University Press

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Título:
Predictive value of high sensitivity C-reactive protein in patients with ST-elevation myocardial infarction treated with percutaneous coronary intervention
Autor: Ortolani, Paolo ; Marzocchi, Antonio ; Marrozzini, Cinzia ; Palmerini, Tullio ; Saia, Francesco ; Taglieri, Nevio ; Baldazzi, Federica ; Silenzi, Simona ; Bacchi-Reggiani, Maria Letizia ; Guastaroba, Paolo ; Grilli, Roberto ; Branzi, Angelo
Assuntos: Aged ; Angioplasty ; Angioplasty, Balloon, Coronary ; Biological and medical sciences ; C-Reactive Protein - metabolism ; Cardiology. Vascular system ; Coronary Angiography ; Coronary heart disease ; Diseases of the cardiovascular system ; Female ; Heart ; High-sensitivity C-reactive protein ; Hospital Mortality ; Humans ; Male ; Medical sciences ; Middle Aged ; Myocardial infarction ; Myocardial Infarction - metabolism ; Myocardial Infarction - mortality ; Myocardial Infarction - therapy ; Myocarditis. Cardiomyopathies ; Percutaneous coronary ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Regression Analysis ; Sensitivity and Specificity ; Transluminal ; Treatment Outcome
É parte de: European heart journal, 2008-05, Vol.29 (10), p.1241-1249
Notas: ArticleID:ehm338
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SourceType-Scholarly Journals-1
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Descrição: Aims To evaluate the predictive value of high sensitivity (hs) C-reactive protein levels on long-term survival in patients with ST-elevation myocardial infarction (STEMI) treated with primary PCI. Methods and results We conducted a retrospective analysis of 758 STEMI patients (from January 2003 to December 2005), with STEMI onset <12 h and hs-C-reactive protein determination on admission. Patients were classified into four groups [I (hs-C-reactive protein < 0.48 mg/dL), II (hs-C-reactive protein ≥ 0.48 to <1.2 mg/dL), III (hs-C-reactive protein ≥ 1.2 to <3.1 mg/dL), IV (hs-C-reactive protein ≥ 3.1 mg/dL)] according to quartiles of hs-C-reactive protein serum level. The IV quartile hs-C-reactive protein group had a higher incidence of in-hospital mortality and cumulative adverse events. At a mean follow-up of 724 ± 376 days (range 0–1393), the IV quartile hs-C-reactive protein group showed lower estimated survival, lower estimated myocardial infarction-free survival and lower estimated event-free survival. At multivariable analysis hs-C-reactive protein appeared to be an independent predictor of long-term mortality (HR: 1.04, 95% CI: 1.01–1.07, P = 0.003), long-term mortality and re-infarction (HR: 1.03, 95% CI: 1.01–1.06, P = 0.008) and adverse events (HR: 1.03, 95% CI: 1.01–1.05, P = 0.03). Conclusion Evaluation of hs-C-reactive protein on admission in STEMI patients undergoing primary PCI allows reliable risk stratification of these patients.
Editor: Oxford: Oxford University Press
Idioma: Inglês

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Predictive value of high sensitivity C-reactive protein in patients with ST-elevation myocardial infarction treated with percutaneous coronary intervention

Ortolani, Paolo ; Marzocchi, Antonio ; Marrozzini, Cinzia ; Palmerini, Tullio ; Saia, Francesco ; Taglieri, Nevio ; Baldazzi, Federica ; Silenzi, Simona ; Bacchi-Reggiani, Maria Letizia ; Guastaroba, Paolo ; Grilli, Roberto ; Branzi, Angelo

Oxford: Oxford University Press

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