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Cytoplasmic immunoglobulins in chronic lymphocytic leukemia B cells

Pianezze, G ; Gentilini, I ; Casini, M ; Fabris, P ; Coser, P

Blood, 1987-04, Vol.69 (4), p.1011-1014 [Periódico revisado por pares]

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Título:
Cytoplasmic immunoglobulins in chronic lymphocytic leukemia B cells
Autor: Pianezze, G ; Gentilini, I ; Casini, M ; Fabris, P ; Coser, P
É parte de: Blood, 1987-04, Vol.69 (4), p.1011-1014
Descrição: It is generally assumed that chronic lymphocytic leukemia of B cell origin (B-CLL) is characterized by the presence of surface membrane immunoglobulins (SmIg) and by the absence of cytoplasmic immunoglobulins (CyIg). In a variable number of cases SmIg are not detectable because of their low density on the cellular surface. Because a constant presence of CyIg in 20 subjects suffering from B-CLL has been reported recently, we reexamined 15 SmIg-negative and 10 SmIg- positive B-CLL patients by SmIg and CyIg determinations. We used a direct immunofluorescence method on peripheral blood mononuclear cells for the detection of SmIg and, after fixation, for CyIg. CyIg were detectable in 24 out of 25 cases, with a fluorescence intensity ranging from weak to moderate. The existence of frequent negative results for CyIg determination in B-CLL reported in the literature probably depends on the low sensitivity of the method used. We conclude that CyIg determination is useful in phenotyping every B-CLL patient, especially SmIg-negative ones.
Idioma: Inglês

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