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ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells

MOUSLI, M ; HOPFNER, R ; ABBADY, A-Q ; MONTE, D ; JEANBLANC, M ; OUDET, P ; LOUIS, B ; BRONNER, C

British journal of cancer, 2003-07, Vol.89 (1), p.120-127 [Periódico revisado por pares]

Basingstoke: Nature Publishing Group

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Título:
ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells
Autor: MOUSLI, M ; HOPFNER, R ; ABBADY, A-Q ; MONTE, D ; JEANBLANC, M ; OUDET, P ; LOUIS, B ; BRONNER, C
Assuntos: Binding sites ; Biochemistry, Molecular Biology ; Biological and medical sciences ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - physiopathology ; Cancer research ; CCAAT-Enhancer-Binding Proteins - biosynthesis ; CCAAT-Enhancer-Binding Proteins - chemistry ; Cell Cycle ; Cell Cycle Proteins ; Cell Transformation, Neoplastic ; DNA-Binding Proteins ; Drugs ; E2F Transcription Factors ; E2F1 Transcription Factor ; Fibroblasts ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Life Sciences ; Medical research ; Medical sciences ; Molecular and Cellular Pathology ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Neoplasms - genetics ; Neoplasms - physiopathology ; Proteins ; Transcription Factors - biosynthesis ; Transcription Factors - pharmacology ; Tumor Cells, Cultured ; Tumors ; Ubiquitin-Protein Ligases ; Up-Regulation
É parte de: British journal of cancer, 2003-07, Vol.89 (1), p.120-127
Notas: PMCID: PMC2394215
These authors are equal first authors.
Descrição: ICBP90 (Inverted CCAAT box Binding Protein of 90 kDa) is a recently identified nuclear protein that binds to one of the inverted CCAAT boxes of the topoisomerase IIalpha (TopoIIalpha) gene promoter. Here, we show that ICBP90 shares structural homology with several other proteins, including Np95, the human and mouse NIRF, suggesting the emergence of a new family of nuclear proteins. Towards elucidating the functions of this family, we analysed the expression of ICBP90 in various cancer or noncancer cell lines and in normal or breast carcinoma tissues. We found that cancer cell lines express higher levels of ICBP90 and TopoIIalpha than noncancer cell lines. By using cell-cycle phase-blocking drugs, we show that in primary cultured human lung fibroblasts, ICBP90 expression peaks at late G1 and during G2/M phases. In contrast, cancer cell lines such as HeLa, Jurkat and A549 show constant ICBP90 expression throughout the entire cell cycle. The effect of overexpression of E2F-1 is more efficient on ICBP90 and TopoIIalpha expression in noncancer cells (IMR90, WI38) than in cancer cells (U2OS, SaOs). Together, these results show that ICBP90 expression is altered in cancer cell lines and is upregulated by E2F-1 overexpression with an efficiency depending on the cancer status of the cell line.
Editor: Basingstoke: Nature Publishing Group
Idioma: Inglês

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ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells

MOUSLI, M ; HOPFNER, R ; ABBADY, A-Q ; MONTE, D ; JEANBLANC, M ; OUDET, P ; LOUIS, B ; BRONNER, C

Basingstoke: Nature Publishing Group

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