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Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia

Martins-de-Souza, Daniel ; Gattaz, Wagner F ; Schmitt, Andrea ; Maccarrone, Giuseppina ; Hunyadi-Gulyás, Eva ; Eberlin, Marcos N ; Souza, Gustavo H.M.F ; Marangoni, Sérgio ; Novello, José C ; Turck, Christoph W ; Dias-Neto, Emmanuel

Journal of psychiatric research, 2009-07, Vol.43 (11), p.978-986 [Periódico revisado por pares]

Kidlington: Elsevier Ltd

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Título:
Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia
Autor: Martins-de-Souza, Daniel ; Gattaz, Wagner F ; Schmitt, Andrea ; Maccarrone, Giuseppina ; Hunyadi-Gulyás, Eva ; Eberlin, Marcos N ; Souza, Gustavo H.M.F ; Marangoni, Sérgio ; Novello, José C ; Turck, Christoph W ; Dias-Neto, Emmanuel
Assuntos: Adult ; Adult and adolescent clinical studies ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers - metabolism ; Cortex ; Cytoskeleton ; Cytoskeleton - metabolism ; Dorsolateral prefrontal cortex ; Electrophoresis, Gel, Two-Dimensional - methods ; Energy Metabolism - physiology ; Female ; Gene Expression Regulation ; Humans ; Male ; Medical sciences ; Metabolism ; Middle Aged ; Mitochondria ; Myelinization ; Oligodendroglia - metabolism ; Peptide Mapping - methods ; Prefrontal Cortex - metabolism ; Proteins ; Proteomics ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Schizophrenia ; Schizophrenia - pathology ; Schizophrenia - physiopathology ; Spectrometry ; Tandem Mass Spectrometry - methods
É parte de: Journal of psychiatric research, 2009-07, Vol.43 (11), p.978-986
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SourceType-Scholarly Journals-1
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Descrição: Abstract Schizophrenia is likely to be a consequence of serial alterations in a number of genes that, together with environmental factors, will lead to the establishment of the illness. The dorsolateral prefrontal cortex (Brodmann’s Area 46) is implicated in schizophrenia and executes high functions such as working memory, differentiation of conflicting thoughts, determination of right and wrong concepts, correct social behavior and personality expression. We performed a comparative proteome analysis using two-dimensional gel electrophoresis of pools from 9 schizophrenia and 7 healthy control patients’ dorsolateral prefrontal cortex aiming to identify, by mass spectrometry, alterations in protein expression that could be related to the disease. In schizophrenia-derived samples, our analysis revealed 10 downregulated and 14 upregulated proteins. These included alterations previously implicated in schizophrenia, such as oligodendrocyte-related proteins (myelin basic protein and transferrin), as well as malate dehydrogenase, aconitase, ATP synthase subunits and cytoskeleton-related proteins. Also, six new putative disease markers were identified, including energy metabolism, cytoskeleton and cell signaling proteins. Our data not only reinforces the involvement of proteins previously implicated in schizophrenia, but also suggests new markers, providing further information to foster the comprehension of this important disease.
Editor: Kidlington: Elsevier Ltd
Idioma: Inglês

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Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia

Martins-de-Souza, Daniel ; Gattaz, Wagner F ; Schmitt, Andrea ; Maccarrone, Giuseppina ; Hunyadi-Gulyás, Eva ; Eberlin, Marcos N ; Souza, Gustavo H.M.F ; Marangoni, Sérgio ; Novello, José C ; Turck, Christoph W ; Dias-Neto, Emmanuel

Kidlington: Elsevier Ltd

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