Idioma:

Distinct genetic architectures and environmental factors associate with host response to the γ2-herpesvirus infections

Sallah, Neneh ; Miley, Wendell ; Labo, Nazzarena ; Carstensen, Tommy ; Fatumo, Segun ; Gurdasani, Deepti ; Pollard, Martin O ; Dilthey, Alexander T ; Mentzer, Alexander J ; Marshall, Vickie ; Cornejo Castro, Elena M ; Pomilla, Cristina ; Young, Elizabeth H ; Asiki, Gershim ; Hibberd, Martin L ; Sandhu, Manjinder ; Kellam, Paul ; Newton, Robert ; Whitby, Denise ; Barroso, Inês

Nature communications, 2020-07, Vol.11 (1), p.3849-13, Article 3849 [Periódico revisado por pares]

England: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Distinct genetic architectures and environmental factors associate with host response to the γ2-herpesvirus infections
Autor: Sallah, Neneh ; Miley, Wendell ; Labo, Nazzarena ; Carstensen, Tommy ; Fatumo, Segun ; Gurdasani, Deepti ; Pollard, Martin O ; Dilthey, Alexander T ; Mentzer, Alexander J ; Marshall, Vickie ; Cornejo Castro, Elena M ; Pomilla, Cristina ; Young, Elizabeth H ; Asiki, Gershim ; Hibberd, Martin L ; Sandhu, Manjinder ; Kellam, Paul ; Newton, Robert ; Whitby, Denise ; Barroso, Inês
Assuntos: Adolescent ; Adult ; Antibodies ; Antibodies, Viral - biosynthesis ; Antibody response ; Antigens ; Antigens, Viral - genetics ; Antigens, Viral - immunology ; Capsid Proteins - genetics ; Capsid Proteins - immunology ; Coinfection ; Disease Resistance - genetics ; Disease transmission ; DQA1 protein ; EBNA-1 protein ; Environmental factors ; Epidemiology ; Epstein-Barr virus ; Epstein-Barr Virus Infections - epidemiology ; Epstein-Barr Virus Infections - genetics ; Epstein-Barr Virus Infections - immunology ; Epstein-Barr Virus Infections - virology ; Epstein-Barr Virus Nuclear Antigens - genetics ; Epstein-Barr Virus Nuclear Antigens - immunology ; Female ; Gene Expression ; Gene mapping ; Genetic analysis ; Genetic factors ; Genome-wide association studies ; Genome-Wide Association Study ; Genomes ; Geographical variations ; Henipavirus Infections - epidemiology ; Henipavirus Infections - genetics ; Henipavirus Infections - immunology ; Henipavirus Infections - virology ; Herpes viruses ; Herpesvirus 4, Human - genetics ; Herpesvirus 4, Human - immunology ; Herpesvirus 4, Human - pathogenicity ; Herpesvirus 8, Human - genetics ; Herpesvirus 8, Human - immunology ; Herpesvirus 8, Human - pathogenicity ; Histocompatibility antigen HLA ; HIV ; HIV - genetics ; HIV - immunology ; HIV - pathogenicity ; HLA-DQ alpha-Chains - genetics ; HLA-DQ alpha-Chains - immunology ; Host-Pathogen Interactions - genetics ; Host-Pathogen Interactions - immunology ; Human immunodeficiency virus ; Humans ; Immunogenicity ; Incidence ; Infections ; Kaposi's sarcoma ; Leukocytes ; Male ; Mapping ; Middle Aged ; Pathogenesis ; Rural areas ; Rural Population ; Sarcoma ; Sarcoma, Kaposi - epidemiology ; Sarcoma, Kaposi - genetics ; Sarcoma, Kaposi - immunology ; Sarcoma, Kaposi - virology ; Uganda - epidemiology ; Urban Population ; Viruses
É parte de: Nature communications, 2020-07, Vol.11 (1), p.3849-13, Article 3849
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr Virus (EBV) establish life-long infections and are associated with malignancies. Striking geographic variation in incidence and the fact that virus alone is insufficient to cause disease, suggests other co-factors are involved. Here we present epidemiological analysis and genome-wide association study (GWAS) in 4365 individuals from an African population cohort, to assess the influence of host genetic and non-genetic factors on virus antibody responses. EBV/KSHV co-infection (OR = 5.71(1.58-7.12)), HIV positivity (OR = 2.22(1.32-3.73)) and living in a more rural area (OR = 1.38(1.01-1.89)) are strongly associated with immunogenicity. GWAS reveals associations with KSHV antibody response in the HLA-B/C region (p = 6.64 × 10 ). For EBV, associations are identified for VCA (rs71542439, p = 1.15 × 10 ). Human leucocyte antigen (HLA) and trans-ancestry fine-mapping substantiate that distinct variants in HLA-DQA1 (p = 5.24 × 10 ) are driving associations for EBNA-1 in Africa. This study highlights complex interactions between KSHV and EBV, in addition to distinct genetic architectures resulting in important differences in pathogenesis and transmission.
Editor: England: Nature Publishing Group
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 6 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Distinct genetic architectures and environmental factors associate with host response to the γ2-herpesvirus infections

England: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.