Idioma:

Telomere length variation in normal epithelial cells adjacent to tumor: potential biomarker for breast cancer local recurrence

Zhou, Xin ; Meeker, Alan K ; Makambi, Kepher H ; Kosti, Ourania ; Kallakury, Bhaskar V.S ; Sidawy, Mary K ; Loffredo, Christopher A ; Zheng, Yun-Ling

Carcinogenesis (New York), 2012-01, Vol.33 (1), p.113-118 [Periódico revisado por pares]

Oxford: Oxford University Press

Texto completo disponível

Citações Citado por

Enviar para

Título:
Telomere length variation in normal epithelial cells adjacent to tumor: potential biomarker for breast cancer local recurrence
Autor: Zhou, Xin ; Meeker, Alan K ; Makambi, Kepher H ; Kosti, Ourania ; Kallakury, Bhaskar V.S ; Sidawy, Mary K ; Loffredo, Christopher A ; Zheng, Yun-Ling
Assuntos: Adult ; Aged ; Biological and medical sciences ; biomarkers ; Biomarkers, Tumor ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Cancer Biomarkers and Molecular Epidemiology ; Carcinogenesis ; Carcinogenesis, carcinogens and anticarcinogens ; Case-Control Studies ; Decision making ; Dose-response effects ; Epithelial cells ; Epithelial Cells - ultrastructure ; Female ; Fluorescence in situ hybridization ; Formaldehyde ; Gynecology. Andrology. Obstetrics ; Humans ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Neoplasm Recurrence, Local - genetics ; Neoplasm Recurrence, Local - pathology ; Stromal Cells - ultrastructure ; Surgery ; Telomere ; Telomeres ; Tumors
É parte de: Carcinogenesis (New York), 2012-01, Vol.33 (1), p.113-118
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Descrição: A better understanding of the risk of local recurrence (LR) will facilitate therapeutic decision making in the management of early breast cancers. In the present study, we investigated whether telomere length in the normal breast epithelial cells surrounding the tumor is predictive of breast cancer LR; 152 women who were diagnosed with breast cancer at the Lombardi Comprehensive Cancer Center were included in this nested case-control study. Cases (patients had LR) and controls (patients had no LR) were matched on year of surgery, age at diagnosis and type of surgery. Telomere fluorescent in situ hybridization was used to determine the telomere length using formalin fixed paraffin-embedded breast tissues. Small telomere length variation (TLV), defined as the coefficient variation of telomere lengths among examined cells, in normal epithelial cells adjacent to the tumor was significantly associated with a 5-fold (95% confidence interval = 1.2-22.2) increased risk of breast cancer LR. When the subjects were categorized into quartiles, a significant inverse dose-response relationship was observed with lowest versus highest quartile odds ratio of 15.3 (P trend = 0.012). Patients who had large TLV had significantly better 10 year recurrence free survival rate compared with patients who had small TLV (80 versus 33%). The present study revealed that TLV in normal epithelial cells adjacent to tumor is a strong predictor of breast cancer LR. If confirmed by future studies, TLV in normal epithelial cells adjacent to tumor has the potential to become a promising biomarker for predicting breast cancer LR after breast conserving surgery.
Editor: Oxford: Oxford University Press
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Telomere length variation in normal epithelial cells adjacent to tumor: potential biomarker for breast cancer local recurrence

Zhou, Xin ; Meeker, Alan K ; Makambi, Kepher H ; Kosti, Ourania ; Kallakury, Bhaskar V.S ; Sidawy, Mary K ; Loffredo, Christopher A ; Zheng, Yun-Ling

Oxford: Oxford University Press

Buscando em bases de dados remotas. Favor aguardar.