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Prognostic value of cardiac troponin T in patients with moderate to severe heart failure scheduled for cardiac resynchronization therapy

Aarones, Marit, MD ; Gullestad, Lars, MD, PhD ; Aakhus, Svend, MD, PhD ; Ueland, Thor, PhD ; Skaardal, Rita, BSc, RN ; Aass, Halfdan, MD, PhD ; Wergeland, Ragnhild, MS ; Smith, Hans-Jørgen, MD, PhD ; Aukrust, Pål, MD, PhD ; Kongsgaard, Erik, MD, PhD

The American heart journal, 2011-06, Vol.161 (6), p.1031-1037 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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Título:
Prognostic value of cardiac troponin T in patients with moderate to severe heart failure scheduled for cardiac resynchronization therapy
Autor: Aarones, Marit, MD ; Gullestad, Lars, MD, PhD ; Aakhus, Svend, MD, PhD ; Ueland, Thor, PhD ; Skaardal, Rita, BSc, RN ; Aass, Halfdan, MD, PhD ; Wergeland, Ragnhild, MS ; Smith, Hans-Jørgen, MD, PhD ; Aukrust, Pål, MD, PhD ; Kongsgaard, Erik, MD, PhD
Assuntos: Aged ; Biological and medical sciences ; Cardiac Resynchronization Therapy ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Coronary vessels ; Creatinine - blood ; Female ; Gender ; Heart ; Heart attacks ; Heart failure ; Heart Failure - blood ; Heart Failure - mortality ; Heart Failure - therapy ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Humans ; Immunoassay ; Magnetic Resonance Imaging, Cine ; Male ; Medical prognosis ; Medical sciences ; Middle Aged ; Mortality ; Multivariate Analysis ; Natriuretic Peptide, Brain - blood ; Ostomy ; Peptide Fragments - blood ; Prognosis ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Regression analysis ; Sinuses ; Survival Analysis ; Troponin T - blood
É parte de: The American heart journal, 2011-06, Vol.161 (6), p.1031-1037
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Background Predicting response to cardiac resynchronization therapy (CRT) is challenging. Highly sensitive cardiac troponin T (hsTnT) might predict response to CRT and identify patients at a high risk of experiencing severe cardiovascular events. We investigated whether baseline levels of hsTnT were associated with response to CRT and with severe cardiovascular events after long-term follow-up. Methods Eighty-one consecutive patients were included according to the current guidelines for CRT. Biochemical, functional, and clinical parameters were assessed at baseline and at 3, 6, and 12 months of follow-up; and mortality/cardiac transplantation after 46 ± 6 months of follow-up was investigated. Cardiac magnetic resonance imaging and echocardiography were used to assess left ventricular function including viability and remodeling. Results Seventy-five patients completed 12 months of follow-up; and after a follow-up of 46 ± 6 months, a total of 15 patients died, 13 of these from cardiovascular causes, and 7 underwent heart transplantation. Baseline hsTnT <15 ng/L predicted response to CRT and was associated with a more favorable outcome with regard to severe cardiovascular events. Multivariate analysis found that presence of transmural scar tissue/fibrosis on magnetic resonance imaging and use of statins were independently associated with higher concentrations of hsTnT at baseline. There was a strong correlation between hsTnT and N-terminal pro–B-type natriuretic peptide levels. Conclusions Highly sensitive TnT levels were elevated in the majority of heart failure patients who were scheduled for CRT. The HsTnT levels predicted response to CRT as well as long-time survival.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

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Prognostic value of cardiac troponin T in patients with moderate to severe heart failure scheduled for cardiac resynchronization therapy

Aarones, Marit, MD ; Gullestad, Lars, MD, PhD ; Aakhus, Svend, MD, PhD ; Ueland, Thor, PhD ; Skaardal, Rita, BSc, RN ; Aass, Halfdan, MD, PhD ; Wergeland, Ragnhild, MS ; Smith, Hans-Jørgen, MD, PhD ; Aukrust, Pål, MD, PhD ; Kongsgaard, Erik, MD, PhD

New York, NY: Elsevier Inc

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