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Probiotic supplementation can positively affect anxiety and depressive symptoms: a systematic review of randomized controlled trials

Pirbaglou, Meysam ; Katz, Joel ; de Souza, Russell J ; Stearns, Jennifer C ; Motamed, Mehras ; Ritvo, Paul

Nutrition research (New York, N.Y.), 2016-09, Vol.36 (9), p.889-898 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Probiotic supplementation can positively affect anxiety and depressive symptoms: a systematic review of randomized controlled trials
  • Autor: Pirbaglou, Meysam ; Katz, Joel ; de Souza, Russell J ; Stearns, Jennifer C ; Motamed, Mehras ; Ritvo, Paul
  • Assuntos: Affect ; Animals ; Anxiety ; Anxiety - drug therapy ; Depression ; Depression - drug therapy ; Dietary Supplements ; Gastroenterology and Hepatology ; Gastrointestinal Microbiome ; Humans ; Mental Health ; Probiotic supplementation ; Probiotics - therapeutic use ; Systematic review
  • É parte de: Nutrition research (New York, N.Y.), 2016-09, Vol.36 (9), p.889-898
  • Notas: SourceType-Scholarly Journals-1
    ObjectType-Feature-4
    ObjectType-Undefined-1
    content type line 23
    ObjectType-Review-2
    ObjectType-Article-3
  • Descrição: Abstract Gastrointestinal microbiota, consisting of microbial communities in the gastrointestinal tract, play an important role in digestive, metabolic, and immune functioning. Preclinical studies on rodents have linked behavioral and neurochemical changes in the central nervous system with deficits or alterations in these bacterial communities. Moreover, probiotic supplementation in rodents has been shown to markedly change behavior, with correlated changes in central neurochemistry. While such studies have documented behavioral and mood-related supplementation effects, the significance of these effects in humans, especially in relation to anxiety and depression symptoms are relatively unknown. Thus, the purpose of this paper was to systematically evaluate current literature on the impact of probiotic supplementation on anxiety and depression symptoms in humans. To this end, multiple databases, including Medline, PsycINFO, PubMed, Scopus, and Web of Science were searched for randomized controlled trials (RCTs) published between January 1990 and January 2016. Search results led to a total of 10 RCTs (4 in clinically diagnosed and 6 in non-clinical samples) that provided limited support for the use of some probiotics in reducing human anxiety and depression. Despite methodological limitations of the included trials and the complex nature of gut-brain interactions, results suggest the detection of apparent psychological benefits from probiotic supplementation. Nevertheless a better understanding of developmental, modulatory, and metagenomic influences on the GI mictobiota, specifically as they relate to mood and mental health, represent strong priorities for future research in this area.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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