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Management of multidrug resistant Gram-negative bacilli infections in solid organ transplant recipients: SET/GESITRA-SEIMC/REIPI recommendations

Aguado, José María ; Silva, J. T ; Fernández Ruiz, Mario ; Cordero, Elisa ; Fortún, Jesús ; Gudiol González, Carlota ; Martínez Martínez, L ; Vidal, Elisa ; Almenar, Luis ; Almirante, Benito ; Cantón, Rafael ; Carratalà, Jordi ; Caston, J. J ; Cercenado, E ; Cervera, Carlos ; Cisneros, José Miguel ; Crespo Leiro, María G ; Cuervas Mons, Valentín ; Elizalde Fernández, J ; Fariñas, María Carmen ; Gavaldà, Joan ; Goyanes, M. J ; Gutiérrez Gutiérrez, B ; Hernández, D ; Len, Óscar ; López Andújar, Rafael ; López Medrano, Francisco ; Martín Dávila, Pilar ; Montejo, Miguel ; Moreno Camacho, Ma. Asunción ; Oliver, Antonio ; Pascual López, Antonio ; Pérez Nadales, E ; Román Broto, A ; San Juan, Rafael ; Serón Micas, Daniel ; Solé- over, A ; Valerio, Maricela ; Muñoz, P ; Torre Cisneros, Julián

Elsevier 2018-01

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Título:
Management of multidrug resistant Gram-negative bacilli infections in solid organ transplant recipients: SET/GESITRA-SEIMC/REIPI recommendations
Autor: Aguado, José María ; Silva, J. T ; Fernández Ruiz, Mario ; Cordero, Elisa ; Fortún, Jesús ; Gudiol González, Carlota ; Martínez Martínez, L ; Vidal, Elisa ; Almenar, Luis ; Almirante, Benito ; Cantón, Rafael ; Carratalà, Jordi ; Caston, J. J ; Cercenado, E ; Cervera, Carlos ; Cisneros, José Miguel ; Crespo Leiro, María G ; Cuervas Mons, Valentín ; Elizalde Fernández, J ; Fariñas, María Carmen ; Gavaldà, Joan ; Goyanes, M. J ; Gutiérrez Gutiérrez, B ; Hernández, D ; Len, Óscar ; López Andújar, Rafael ; López Medrano, Francisco ; Martín Dávila, Pilar ; Montejo, Miguel ; Moreno Camacho, Ma. Asunción ; Oliver, Antonio ; Pascual López, Antonio ; Pérez Nadales, E ; Román Broto, A ; San Juan, Rafael ; Serón Micas, Daniel ; Solé- over, A ; Valerio, Maricela ; Muñoz, P ; Torre Cisneros, Julián
Assuntos: Bacillus (Bacteria) ; Bacils ; Communicable diseases ; Malalties infeccioses ; Pseudomonas ; Transplantation of organs ; Trasplantament d'òrgans
Notas: Articles publicats en revistes (Medicina)
Versió postprint del document publicat a: https://doi.org/10.1016/j.trre.2017.07.001
https://doi.org/10.1016/j.trre.2017.07.001
http://hdl.handle.net/2445/131300
676788
0955-470X
Transplantation Reviews, 2018, vol. 32, num. 1, p. 36-57
Descrição: Solid organ transplant (SOT) recipients are especially at risk of developing infections by multidrug resistant (MDR) Gram-negative bacilli (GNB), as they are frequently exposed to antibiotics and the healthcare setting, and are regulary subject to invasive procedures. Nevertheless, no recommendations concerning prevention and treatment are available. A panel of experts revised the available evidence; this document summarizes their recommendations: (1) it is important to characterize the isolate's phenotypic and genotypic resistance profile; (2) overall, donor colonization should not constitute a contraindication to transplantation, although active infected kidney and lung grafts should be avoided; (3) recipient colonization is associated with an increased risk of infection, but is not a contraindication to transplantation; (4) different surgical prophylaxis regimens are not recommended for patients colonized with carbapenem-resistant GNB; (5) timely detection of carriers, contact isolation precautions, hand hygiene compliance and antibiotic control policies are important preventive measures; (6) there is not sufficient data to recommend intestinal decolonization; (7) colonized lung transplant recipients could benefit from prophylactic inhaled antibiotics, specially for Pseudomonas aeruginosa; (8) colonized SOT recipients should receive an empirical treatment which includes active antibiotics, and directed therapy should be adjusted according to susceptibility study results and the severity of the infection.
Editor: Elsevier
Data de criação/publicação: 2018-01
Idioma: Inglês

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Management of multidrug resistant Gram-negative bacilli infections in solid organ transplant recipients: SET/GESITRA-SEIMC/REIPI recommendations

Elsevier 2018-01

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