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The prevalence of late-follicular phase progesterone elevation and impact on the ongoing pregnancy rate after fresh and frozen blastocyst transfer. Sub-study of an RCT

Stormlund, Sacha ; Sopa, Negjyp ; Lyng Forman, Julie ; Zedeler, Anne ; Bogstad, Jeanette ; Prætorius, Lisbeth ; Nielsen, Henriette Svarre ; Klajnbard, Anna ; Englund, Anne Lis ; Ziebe, Søren ; Freiesleben, Nina la Cour ; Bergh, Christina ; Humaidan, Peter ; Nyboe Andersen, Anders ; Pinborg, Anja ; Løssl, Kristine

Human fertility (Cambridge, England), 2024-12, Vol.27 (1), p.2265153-2265153 [Periódico revisado por pares]

England

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Título:
The prevalence of late-follicular phase progesterone elevation and impact on the ongoing pregnancy rate after fresh and frozen blastocyst transfer. Sub-study of an RCT
Autor: Stormlund, Sacha ; Sopa, Negjyp ; Lyng Forman, Julie ; Zedeler, Anne ; Bogstad, Jeanette ; Prætorius, Lisbeth ; Nielsen, Henriette Svarre ; Klajnbard, Anna ; Englund, Anne Lis ; Ziebe, Søren ; Freiesleben, Nina la Cour ; Bergh, Christina ; Humaidan, Peter ; Nyboe Andersen, Anders ; Pinborg, Anja ; Løssl, Kristine
Assuntos: Embryo Transfer ; Female ; Fertilization in Vitro ; Follicular Phase ; Frozen embryo transfer ; Humans ; In vitro fertilisation ; Obstetrics, Gynecology and Reproductive Medicine ; Ongoing pregnancy rate ; Ovulation Induction ; Pregnancy ; Pregnancy Rate ; Prevalence ; Progesterone ; Reproduktionsmedicin och gynekologi ; Serum Progesterone
É parte de: Human fertility (Cambridge, England), 2024-12, Vol.27 (1), p.2265153-2265153
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: The effect of late-follicular phase progesterone elevation (LFPE) during ovarian stimulation on reproductive outcomes in ART treatment remains controversial, but recent studies indicate lower pregnancy rates with rising progesterone levels. This study aims to investigate the prevalence of late-follicular phase progesterone elevation (LFPE) and possible impact on ongoing pregnancy rate after fresh or frozen blastocyst transfer in a sub-study setting of a randomised controlled trial. A total of 288 women were included (n=137 and n=151 in the fresh transfer and freeze-all group, respectively). Among these 11(3.8%) had a progesterone level ≥1.5 ng/ml, and 20(6.9%) had a progesterone level ≥1.2 ng/ml on . Spline regression analysis showed no significant effect of late follicular phase progesterone levels on ongoing pregnancy. In the multivariate regression analysis ( = 312) only age, but not progesterone level on was significantly associated with ongoing pregnancy. In conclusion, in a clinical setting with moderate gonadotrophin stimulation and well-defined trigger and fresh transfer cancellation criteria, the prevalence of women with LFPE ≥1.5 ng/ml was low and did not indicate the clinical value of routine measurement of progesterone in the late follicular phase.
Editor: England
Idioma: Inglês

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The prevalence of late-follicular phase progesterone elevation and impact on the ongoing pregnancy rate after fresh and frozen blastocyst transfer. Sub-study of an RCT

England

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