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Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes

Ledur, Pitia Flores ; Karmirian, Karina ; Gouveia Pedrosa, Carolina da Silva ; Quintino Souza, Leticia Rocha ; Assis-de-Lemos, Gabriela ; Martins, Thiago Martino ; Cavalheiro Gomes Ferreira, Jessica de Cassia ; de Azevedo Reis, Gabriel Ferreira ; Silva, Eduardo Santos ; Silva, Debora ; Salerno, Jose Alexandre ; Ornelas, Isis Moraes ; Devalle, Sylvie ; Madeiro da Costa, Rodrigo Furtado ; Goto-Silva, Livia ; Higa, Luiza Mendonca ; Melo, Adriana ; Tanuri, Amilcar ; Chimelli, Leila ; Murata, Marcos Massao ; Garcez, Patricia Pestana ; Filippi-Chiela, Eduardo Cremonese ; Galina, Antonio ; Borges, Helena Lobo ; Rehen, Stevens Kastrup

SCIENTIFIC REPORTS, 2020-01, Vol.10 (1) [Periódico revisado por pares]

NATURE RESEARCH

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Título:
Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes
Autor: Ledur, Pitia Flores ; Karmirian, Karina ; Gouveia Pedrosa, Carolina da Silva ; Quintino Souza, Leticia Rocha ; Assis-de-Lemos, Gabriela ; Martins, Thiago Martino ; Cavalheiro Gomes Ferreira, Jessica de Cassia ; de Azevedo Reis, Gabriel Ferreira ; Silva, Eduardo Santos ; Silva, Debora ; Salerno, Jose Alexandre ; Ornelas, Isis Moraes ; Devalle, Sylvie ; Madeiro da Costa, Rodrigo Furtado ; Goto-Silva, Livia ; Higa, Luiza Mendonca ; Melo, Adriana ; Tanuri, Amilcar ; Chimelli, Leila ; Murata, Marcos Massao ; Garcez, Patricia Pestana ; Filippi-Chiela, Eduardo Cremonese ; Galina, Antonio ; Borges, Helena Lobo ; Rehen, Stevens Kastrup
É parte de: SCIENTIFIC REPORTS, 2020-01, Vol.10 (1)
Descrição: Zika virus (ZIKV) has been extensively studied since it was linked to congenital malformations, and recent research has revealed that astrocytes are targets of ZIKV. However, the consequences of ZIKV infection, especially to this cell type, remain largely unknown, particularly considering integrative studies aiming to understand the crosstalk among key cellular mechanisms and fates involved in the neurotoxicity of the virus. Here, the consequences of ZIKV infection in iPSC-derived astrocytes are presented. Our results show ROS imbalance, mitochondrial defects and DNA breakage, which have been previously linked to neurological disorders. We have also detected glial reactivity, also present in mice and in post-mortem brains from infected neonates from the Northeast of Brazil. Given the role of glia in the developing brain, these findings may help to explain the observed effects in congenital Zika syndrome related to neuronal loss and motor deficit.
Editor: NATURE RESEARCH
Idioma: Inglês

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Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes

NATURE RESEARCH

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