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Evaluation of Two Live, Cold-Passaged, Temperature-Sensitive Respiratory Syncytial Virus Vaccines in Chimpanzees and in Human Adults, Infants, and Children

Karron, Ruth A. ; Wright, Peter F. ; Crowe, James E. ; Mann, Mary Lou Clements ; Thompson, Juliette ; Makhene, Mamodikoe ; Casey, Roberta ; Murphy, Brian R.

The Journal of infectious diseases, 1997-12, Vol.176 (6), p.1428-1436 [Periódico revisado por pares]

Chicago, IL: The University of Chicago Press

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Título:
Evaluation of Two Live, Cold-Passaged, Temperature-Sensitive Respiratory Syncytial Virus Vaccines in Chimpanzees and in Human Adults, Infants, and Children
Autor: Karron, Ruth A. ; Wright, Peter F. ; Crowe, James E. ; Mann, Mary Lou Clements ; Thompson, Juliette ; Makhene, Mamodikoe ; Casey, Roberta ; Murphy, Brian R.
Assuntos: Adolescent ; Adult ; Animals ; Antibodies ; Antibodies, Viral - analysis ; Antibodies, Viral - biosynthesis ; Antibodies, Viral - blood ; Biological and medical sciences ; Cell Line ; Child, Preschool ; Children ; Double-Blind Method ; Female ; Fluorouracil ; Fundamental and applied biological sciences. Psychology ; Human respiratory syncytial virus ; Humans ; Infant ; Infants ; Major Articles ; Male ; Microbiology ; Middle Aged ; Mutagenesis ; Mutation ; Nasal Lavage Fluid - immunology ; Nasal Lavage Fluid - virology ; Pan troglodytes ; Placebos ; Respiratory Syncytial Virus Infections - immunology ; Respiratory Syncytial Virus Infections - transmission ; Respiratory syncytial virus vaccines ; Respiratory syncytial viruses ; Respiratory Syncytial Viruses - genetics ; Respiratory Syncytial Viruses - immunology ; Respiratory Syncytial Viruses - pathogenicity ; Transcriptional regulatory elements ; Vaccination ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Vaccines, Attenuated - immunology ; Viral Vaccines - immunology ; Virology ; Viruses
É parte de: The Journal of infectious diseases, 1997-12, Vol.176 (6), p.1428-1436
Notas: Reprints or correspondence: Dr. Ruth A. Karron, Center for Immunization Research, Johns Hopkins University School of Hygiene and Public Health, Hampton House 117, 624 N. Broadway, Baltimore, MD 21205.
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Descrição: Two live-attenuated, cold-passaged (cp), temperature-sensitive (ts) candidate vaccines, designated cpts530/1009 and cpts248/955, were attenuated, genetically stable, and immunogenic in chimpanzees and were highly attenuated for human adults. In respiratory syncytial virus (RSV)-seropositive children, cpts530/1009 was more restricted in replication than cpts248/955. In seronegative children, 104 pfu of cpts248/955 was insufficiently attenuated, and a high titer of vaccine virus was shed (mean peak titer, 104.4 pfu/mL), whereas 104 pfu of cpts530/1009 was relatively attenuated and restricted in replication (mean peak titer, 102.0 pfu/mL). At a dose of 105 pfu, cpts530/1009 was immunogenic in seronegative children (geometric mean titer of RSV neutralizing antibodies, 1:724). Transmission of either vaccine to seronegative placebo recipients occurred at a frequency of 20%–25%. Of importance, vaccine viruses recovered from chimpanzees and humans were ts. In contrast to previous studies, this study indicates that live attenuated RSV vaccines that are immunogenic and phenotypically stable can be developed. Additional studies are being conducted to identify a live RSV vaccine that is slightly more attenuated and less transmissible than cpts530/1009.
Editor: Chicago, IL: The University of Chicago Press
Idioma: Inglês

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Evaluation of Two Live, Cold-Passaged, Temperature-Sensitive Respiratory Syncytial Virus Vaccines in Chimpanzees and in Human Adults, Infants, and Children

Karron, Ruth A. ; Wright, Peter F. ; Crowe, James E. ; Mann, Mary Lou Clements ; Thompson, Juliette ; Makhene, Mamodikoe ; Casey, Roberta ; Murphy, Brian R.

Chicago, IL: The University of Chicago Press

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