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Lab-to-Field Transition of RNA Spray Applications – How Far Are We?

Rank, Aline Pereira ; Koch, Aline

Frontiers in plant science, 2021-10, Vol.12, p.755203-755203 [Periódico revisado por pares]

Frontiers Media S.A

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  • Título:
    Lab-to-Field Transition of RNA Spray Applications – How Far Are We?
  • Autor: Rank, Aline Pereira ; Koch, Aline
  • Assuntos: dsRNA ; nanomaterial-based siRNA delivery ; Plant Science ; RNA biopesticides ; RNAi-based plant protection ; siRNA ; spray-induced gene silencing (SIGS)
  • É parte de: Frontiers in plant science, 2021-10, Vol.12, p.755203-755203
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    Reviewed by: Athanasios Dalakouras, Institute of Industrial and Forage Crops, Hellenic Agricultural Organisation, Greece; Clauvis Nji Tizi Taning, Ghent University, Belgium
    This article was submitted to Plant Biotechnology, a section of the journal Frontiers in Plant Science
    Edited by: Antje Dietz-Pfeilstetter, Julius Kühn-Institut - Braunschweig, Germany
  • Descrição: The drastic loss of biodiversity has alarmed the public and raised sociopolitical demand for chemical pesticide-free plant production, which is now treated by governments worldwide as a top priority. Given this global challenge, RNAi-based technologies are rapidly evolving as a promising substitute to conventional chemical pesticides. Primarily, genetically modified (GM) crops expressing double-stranded (ds)RNA-mediating gene silencing of foreign transcripts have been developed. However, since the cultivation of GM RNAi crops is viewed negatively in numerous countries, GM-free exogenous RNA spray applications attract tremendous scientific and political interest. The sudden rise in demand for pesticide alternatives has boosted research on sprayable RNA biopesticides, generating significant technological developments and advancing the potential for field applications in the near future. Here we review the latest advances that could pave the way for a quick lab-to-field transition for RNA sprays, which, as safe, selective, broadly applicable, and cost-effective biopesticides, represent an innovation in sustainable crop production. Given these latest advances, we further discuss technological limitations, knowledge gaps in the research, safety concerns and regulatory requirements that need to be considered and addressed before RNA sprays can become a reliable and realistic agricultural approach.
  • Editor: Frontiers Media S.A
  • Idioma: Inglês

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