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Homocysteine and cognitive impairment in Parkinson's disease: A biochemical, neuroimaging, and genetic study

Rodriguez-Oroz, Maria C. ; Lage, Pablo Martínez ; Sanchez-Mut, Jose ; Lamet, Isabel ; Pagonabarraga, Javier ; Toledo, Jon B. ; García-Garcia, David ; Clavero, Pedro ; Samaranch, Lluis ; Irurzun, Cecilia ; Matsubara, Juan M. ; Irigoien, Jaione ; Bescos, Emilia ; Kulisevsky, Jaime ; Pérez-Tur, Jordi ; Obeso, Jose A.

Movement disorders, 2009-07, Vol.24 (10), p.1437-1444 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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Título:
Homocysteine and cognitive impairment in Parkinson's disease: A biochemical, neuroimaging, and genetic study
Autor: Rodriguez-Oroz, Maria C. ; Lage, Pablo Martínez ; Sanchez-Mut, Jose ; Lamet, Isabel ; Pagonabarraga, Javier ; Toledo, Jon B. ; García-Garcia, David ; Clavero, Pedro ; Samaranch, Lluis ; Irurzun, Cecilia ; Matsubara, Juan M. ; Irigoien, Jaione ; Bescos, Emilia ; Kulisevsky, Jaime ; Pérez-Tur, Jordi ; Obeso, Jose A.
Assuntos: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - genetics ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Brain - pathology ; Carbon-Nitrogen Ligases - genetics ; Case-Control Studies ; Cognition Disorders - blood ; Cognition Disorders - etiology ; Cognition Disorders - genetics ; Cognition Disorders - pathology ; Cystathionine beta-Synthase - genetics ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; dementia ; Depression - etiology ; Female ; Folic Acid - blood ; genetics ; homocysteine ; Homocysteine - blood ; Humans ; Immunoassay - methods ; Logistic Models ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Mental Status Schedule ; Middle Aged ; mild cognitive impairment ; Neurology ; Neuropsychological Tests ; Parkinson Disease - blood ; Parkinson Disease - complications ; Parkinson Disease - genetics ; Parkinson Disease - pathology ; Parkinson's disease ; Polymorphism, Genetic ; Severity of Illness Index ; Vitamin B 12 - blood ; Vitamin B 6 - blood ; white matter hyperintensities
É parte de: Movement disorders, 2009-07, Vol.24 (10), p.1437-1444
Notas: Potential conflict of interest: Nothing to report.
Ministerio de Educación y Ciencia, Spain - No. SAF2006-00724
istex:623F6888A7B960F1E7BF39FC9094613747719D6C
Novartis Pharma (Basel, Switzerland)
ArticleID:MDS22522
Government of Navarra - No. 49/2004
ark:/67375/WNG-76D56BZM-X
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Descrição: The role of the plasma level of homocysteine (Hcy), as a primary outcome, and the effect of silent cerebrovascular lesions and genetic variants related to Hcy metabolism, as secondary outcomes, in the cognitive decline and dementia in Parkinson's disease (PD) were studied. This case–control study focused on 89 PD patients of minimum 10 years of evolution and older than 60 years, who were neuropsychologically classified either as cognitively normal (n = 37), having mild cognitive impairment (Petersen criteria) (n = 22), or suffering from dementia (DSM‐IV) (n = 30), compared with cognitively normal age‐matched control subjects (n = 30). Plasma levels of Hcy, vitamins B12 and B6, folic acid, polymorphisms in genes related to Hcy metabolism (MTHFR, MTR, MTRR, and CBS) and silent cerebrovascular events were analyzed. Plasma levels of Hcy were increased in PD patients (P = 0.0001). There were no differences between the groups of patients. The brain vascular burden was similar among PD groups. There was no association between polymorphisms in the studied genes and the Hcy plasma levels or cognitive status in PD patients. We found no evidence for a direct relationship between Hcy plasma levels and cognitive impairment and dementia in PD. No indirect effect through cerebrovascular disease or genetic background was found either. © 2009 Movement Disorder Society
Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

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Homocysteine and cognitive impairment in Parkinson's disease: A biochemical, neuroimaging, and genetic study

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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