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Multifunctional nanoparticles as coupled contrast agents

O'Donnell, Matthew ; Gao, Xiaohu ; Jin, Yongdong ; Jia, Congxian ; Huang, Sheng-Wen

Nature communications, 2010-07, Vol.1 (4), p.1-8, Article 41 [Periódico revisado por pares]

England: Nature Publishing Group

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  • Título:
    Multifunctional nanoparticles as coupled contrast agents
  • Autor: O'Donnell, Matthew ; Gao, Xiaohu ; Jin, Yongdong ; Jia, Congxian ; Huang, Sheng-Wen
  • Assuntos: Contrast Media - chemistry ; Diagnostic Imaging - methods ; Magnetic Resonance Imaging ; Microscopy, Electron ; Models, Theoretical ; Nanoparticles ; Nanoparticles - chemistry ; Nanotechnology - methods
  • É parte de: Nature communications, 2010-07, Vol.1 (4), p.1-8, Article 41
  • Descrição: Engineering compact imaging probes with highly integrated modalities is a key focus in bionanotechnology and will have profound impact on molecular diagnostics, imaging and therapeutics. However, combining multiple components on a nanometre scale to create new imaging modalities unavailable from individual components has proven to be challenging. In this paper, we demonstrate iron oxide and gold-coupled core-shell nanoparticles (NPs) with well-defined structural characteristics (for example, size, shell thickness and core-shell separation) and physical properties (for example, electronic, magnetic, optical, thermal and acoustic). The resulting multifunctional nanoprobes not only offer contrast for electron microscopy, magnetic resonance imaging and scattering-based imaging but, more importantly, enable a new imaging mode, magnetomotive photoacoustic imaging, with remarkable contrast enhancement compared with photoacoustic images using conventional NP contrast agents.
  • Editor: England: Nature Publishing Group
  • Idioma: Inglês
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