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miR-508-5p regulates multidrug resistance of gastric cancer by targeting ABCB1 and ZNRD1

Shang, Y ; Zhang, Z ; Liu, Z ; Feng, B ; Ren, G ; Li, K ; Zhou, L ; Sun, Y ; Li, M ; Zhou, J ; An, Y ; Wu, K ; Nie, Y ; Fan, D

Oncogene, 2014-06, Vol.33 (25), p.3267-3276 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
miR-508-5p regulates multidrug resistance of gastric cancer by targeting ABCB1 and ZNRD1
Autor: Shang, Y ; Zhang, Z ; Liu, Z ; Feng, B ; Ren, G ; Li, K ; Zhou, L ; Sun, Y ; Li, M ; Zhou, J ; An, Y ; Wu, K ; Nie, Y ; Fan, D
Assuntos: 3' Untranslated Regions ; Animals ; Antineoplastic Agents - pharmacology ; ATP Binding Cassette Transporter, Subfamily B ; ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics ; ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism ; Cancer ; Care and treatment ; Cell Line, Tumor ; Chemotherapy ; Cisplatin - pharmacology ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Doxorubicin - pharmacology ; Drug resistance ; Drug Resistance, Multiple ; Drug Screening Assays, Antitumor ; Fluorouracil - pharmacology ; Gastric cancer ; Gene expression ; Gene Expression Regulation, Neoplastic - drug effects ; Genetic aspects ; Genetic research ; Humans ; Identification and classification ; Medical prognosis ; Mice ; Mice, Nude ; MicroRNA ; MicroRNAs ; MicroRNAs - biosynthesis ; MicroRNAs - genetics ; miRNA ; mRNA ; Multidrug resistance ; Multidrug resistant organisms ; Oncology, Experimental ; Properties ; RNA, Messenger - genetics ; Stomach cancer ; Stomach Neoplasms - drug therapy ; Stomach Neoplasms - genetics ; Stomach Neoplasms - metabolism ; Transfection ; Tumors ; Vincristine - pharmacology ; Xenograft Model Antitumor Assays
É parte de: Oncogene, 2014-06, Vol.33 (25), p.3267-3276
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Multidrug resistance (MDR) is usually correlated with the poor prognosis of gastric cancer. In this study, we revealed a total of 11 microRNAs (miRNA) that regulated MDR of gastric cancer via high-throughput functional screening, and miR-508-5p reversed MDR most efficiently among these candidate miRNAs. The overexpression of miR-508-5p was sufficient to reverse cancer cell resistance to multiple chemotherapeutics in vitro and sensitize tumours to chemotherapy in vivo. Further studies showed that miR-508-5p could directly target the 3'-untranslated regions of ABCB1 and Zinc ribbon domain-containing 1 (ZNRD1), and suppress their expression at the mRNA and protein levels. Meanwhile, the suppression of ZNRD1 led to a decrease in ABCB1. These findings suggest that a miR-508-5p/ZNRD1/ABCB1 regulatory loop has a critical role in MDR in gastric cancer. In addition, miR-508-5p could be used as a prognostic factor for overall survival in gastric cancer. These data reveal an important role for miR-508-5p in the regulation of MDR in gastric cancer, and suggest the potential application of miR-508-5p in drug resistance prediction and treatment.
Editor: England: Nature Publishing Group
Idioma: Inglês

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miR-508-5p regulates multidrug resistance of gastric cancer by targeting ABCB1 and ZNRD1

Shang, Y ; Zhang, Z ; Liu, Z ; Feng, B ; Ren, G ; Li, K ; Zhou, L ; Sun, Y ; Li, M ; Zhou, J ; An, Y ; Wu, K ; Nie, Y ; Fan, D

England: Nature Publishing Group

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