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B cells: The many facets of B cells in allergic diseases

Satitsuksanoa, Pattraporn ; Iwasaki, Sayuri ; Boersma, Jolien ; Imam, Manal Bel ; Schneider, Stephan R. ; Chang, Iris ; van de Veen, Willem ; Akdis, Mübeccel

Journal of allergy and clinical immunology, 2023-09, Vol.152 (3), p.567-581 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    B cells: The many facets of B cells in allergic diseases
  • Autor: Satitsuksanoa, Pattraporn ; Iwasaki, Sayuri ; Boersma, Jolien ; Imam, Manal Bel ; Schneider, Stephan R. ; Chang, Iris ; van de Veen, Willem ; Akdis, Mübeccel
  • Assuntos: Allergen-specific immunotherapy (AIT) ; antibody-secreting cells ; B cells ; IL-10 ; regulatory B (Breg) cells
  • É parte de: Journal of allergy and clinical immunology, 2023-09, Vol.152 (3), p.567-581
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: B cells play a key role in our immune system through their ability to produce antibodies, suppress a proinflammatory state, and contribute to central immune tolerance. We aim to provide an in-depth knowledge of the molecular biology of B cells, including their origin, developmental process, types and subsets, and functions. In allergic diseases, B cells are well known to induce and maintain immune tolerance through the production of suppressor cytokines such as IL-10. Similarly, B cells protect against viral infections such as severe acute respiratory syndrome coronavirus 2 that caused the recent coronavirus disease 2019 pandemic. Considering the unique and multifaceted functions of B cells, we hereby provide a comprehensive overview of the current knowledge of B-cell biology and its clinical applications in allergic diseases, organ transplantation, and cancer.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês

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