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Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus

Kassuya, C.A.L ; Leite, D.F.P ; Melo, L.V. de ; Rehder, V.L.G ; Calixto, J.B

Planta medica, 2005-08, Vol.71 (8), p.721-726 [Periódico revisado por pares]

Stuttgart: Thieme

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Título:
Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus
Autor: Kassuya, C.A.L ; Leite, D.F.P ; Melo, L.V. de ; Rehder, V.L.G ; Calixto, J.B
Assuntos: Administration, Oral ; Animals ; anti-inflammatory activity ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Biological and medical sciences ; Carrageenan ; chemical structure ; Dose-Response Relationship, Drug ; edema ; Edema - chemically induced ; Edema - prevention & control ; enzyme activity ; fractionation ; General pharmacology ; interleukin-1 ; lignans ; Lignans - administration & dosage ; Lignans - pharmacology ; Lignans - therapeutic use ; Male ; Medical sciences ; medicinal plants ; Mice ; neutrophils ; Original Paper ; peroxidase ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phyllanthus ; Phyllanthus amarus ; phytochemicals ; Phytotherapy ; plant biochemistry ; plant extracts ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; spectral analysis ; traditional medicine
É parte de: Planta medica, 2005-08, Vol.71 (8), p.721-726
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Abstract This study assessed the anti-inflammatory effect of the extracts and purified lignans obtained from PHYLLANTHUS AMARUS. Given orally, the hexane extract (HE), the lignan-rich fraction (LRF), or the lignans phyltetralin, nirtetralin, niranthin, but not hypophyllanthin or phyllanthin, inhibited carrageenan (Cg)-induced paw oedema and neutrophil influx. The HE, the LRF or nirtetralin also inhibited the increase of IL1-β tissue levels induced by Cg. Furthermore, bradykinin (BK)-, platelet activating factor (PAF)- and endothelin-1 (ET-1)-induced paw oedema were significantly inhibited by the HE or LRF while histamine- and substance P-induced paw oedema were unaffected. Finally, nirtetralin or phyltetralin caused inhibition of paw oedema induced by PAF or ET-1. These results show that the HE, the LRF and the lignans niranthin, phyltetralin and nirtetralin exhibited marked anti-inflammatory properties and suggest that these lignans seem to be the main active principles responsible for the anti-inflammatory properties reported for the HE of P. AMARUS.
Editor: Stuttgart: Thieme
Idioma: Inglês;Alemão

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Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus

Kassuya, C.A.L ; Leite, D.F.P ; Melo, L.V. de ; Rehder, V.L.G ; Calixto, J.B

Stuttgart: Thieme

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