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Skeletal Muscle Fiber-type Switching, Exercise Intolerance, and Myopathy in PGC-1α Muscle-specific Knock-out Animals

Handschin, Christoph ; Chin, Sherry ; Li, Ping ; Liu, Fenfen ; Maratos-Flier, Eleftheria ; LeBrasseur, Nathan K. ; Yan, Zhen ; Spiegelman, Bruce M.

The Journal of biological chemistry, 2007-10, Vol.282 (41), p.30014-30021 [Periódico revisado por pares]

Elsevier Inc

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  • Título:
    Skeletal Muscle Fiber-type Switching, Exercise Intolerance, and Myopathy in PGC-1α Muscle-specific Knock-out Animals
  • Autor: Handschin, Christoph ; Chin, Sherry ; Li, Ping ; Liu, Fenfen ; Maratos-Flier, Eleftheria ; LeBrasseur, Nathan K. ; Yan, Zhen ; Spiegelman, Bruce M.
  • É parte de: The Journal of biological chemistry, 2007-10, Vol.282 (41), p.30014-30021
  • Notas: http://www.jbc.org/
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  • Descrição: The transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a key integrator of neuromuscular activity in skeletal muscle. Ectopic expression of PGC-1α in muscle results in increased mitochondrial number and function as well as an increase in oxidative, fatigue-resistant muscle fibers. Whole body PGC-1α knock-out mice have a very complex phenotype but do not have a marked skeletal muscle phenotype. We thus analyzed skeletal muscle-specific PGC-1α knock-out mice to identify a specific role for PGC-1α in skeletal muscle function. These mice exhibit a shift from oxidative type I and IIa toward type IIx and IIb muscle fibers. Moreover, skeletal muscle-specific PGC-1α knock-out animals have reduced endurance capacity and exhibit fiber damage and elevated markers of inflammation following treadmill running. Our data demonstrate a critical role for PGC-1α in maintenance of normal fiber type composition and of muscle fiber integrity following exertion.
  • Editor: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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