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The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer’s disease

Liu, Kefu ; Aierken, Ailikemu ; Liu, Mengyao ; Parhat, Nazakat ; Kong, Wei ; Yin, Xingyu ; Liu, Gang ; Yu, Ding ; Hong, Jie ; Ni, Junjun ; Quan, Zhenzhen ; Liu, Xiaoyun ; Ji, Simei ; Mao, Jian ; Peng, Weijun ; Chen, Chao ; Yan, Yan ; Qing, Hong

iScience, 2024-03, Vol.27 (3), p.109281-109281, Article 109281 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer’s disease
  • Autor: Liu, Kefu ; Aierken, Ailikemu ; Liu, Mengyao ; Parhat, Nazakat ; Kong, Wei ; Yin, Xingyu ; Liu, Gang ; Yu, Ding ; Hong, Jie ; Ni, Junjun ; Quan, Zhenzhen ; Liu, Xiaoyun ; Ji, Simei ; Mao, Jian ; Peng, Weijun ; Chen, Chao ; Yan, Yan ; Qing, Hong
  • Assuntos: Biological sciences ; Classification Description ; Disease ; Health sciences
  • É parte de: iScience, 2024-03, Vol.27 (3), p.109281-109281, Article 109281
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    These authors contributed equally
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  • Descrição: Alzheimer’s disease (AD) is the most common neurodegenerative disease often associated with olfactory dysfunction. Aβ is a typical AD hall marker, but Aβ-induced molecular alterations in olfactory memory remain unclear. In this study, we used a 5xFAD mouse model to investigate Aβ-induced olfactory changes. Results showed that 4-month-old 5xFAD have olfactory memory impairment accompanied by piriform cortex neuron activity decline and no sound or working memory impairment. In addition, synapse and glia functional alteration is consistent across different ages at the proteomic level. Microglia and astrocyte specific proteins showed strong interactions in the conserved co-expression network module. Moreover, this interaction declines only in mild cognitive impairment patients in human postmortem brain proteomic data. This suggests that astrocytes-microglia interaction may play a leading role in the early stage of Aβ-induced olfactory memory impairment, and the decreasing of their synergy may accelerate the neurodegeneration. [Display omitted] •Aβ induces olfactory memory impairment by piriform cortex neurons in 5xFAD•Aβ accumulation mainly affects glial cells and synapse abnormal in 5xFAD•Astrocyte-microglia interaction declines appear in 4-month-old 5xFAD and MCI patient Classification Description: Health sciences; Disease; Biological sciences
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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