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Effects of intraocular or systemic administration of neutralizing antibody against vascular endothelial growth factor on the murine experimental model of retinopathy

Sone, Hirohito ; Kawakami, Yasushi ; Kumagai, Arno K. ; Okuda, Yukichi ; Sekine, Yasuo ; Honmura, Sachiko ; Segawa, Toshiaki ; Suzuki, Hideo ; Yamashita, Kamejiro ; Yamada, Nobuhiro

Life sciences (1973), 1999, Vol.65 (24), p.2573-2580 [Periódico revisado por pares]

Netherlands: Elsevier Inc

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Título:
Effects of intraocular or systemic administration of neutralizing antibody against vascular endothelial growth factor on the murine experimental model of retinopathy
Autor: Sone, Hirohito ; Kawakami, Yasushi ; Kumagai, Arno K. ; Okuda, Yukichi ; Sekine, Yasuo ; Honmura, Sachiko ; Segawa, Toshiaki ; Suzuki, Hideo ; Yamashita, Kamejiro ; Yamada, Nobuhiro
Assuntos: animal retinopathy model ; Animals ; Animals, Newborn ; Antibodies - immunology ; Antibodies - pharmacology ; Diabetic Retinopathy - therapy ; Disease Models, Animal ; Endothelial Growth Factors - antagonists & inhibitors ; Endothelial Growth Factors - immunology ; Female ; Humans ; Infant, Newborn ; Injections, Subcutaneous ; intraocular administration ; Lymphokines - antagonists & inhibitors ; Lymphokines - immunology ; Mice ; Mice, Inbred C57BL ; neovascularization ; neutralizing/blocking antibody ; Oxygen - toxicity ; oxygen-induced retinopathy ; Pregnancy ; proliferative retinopathy ; Rabbits ; Retinal Neovascularization - therapy ; Retinopathy of Prematurity - therapy ; vascular endothelial growth factor ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors ; vascular permeability factor
É parte de: Life sciences (1973), 1999, Vol.65 (24), p.2573-2580
Descrição: Vascular endothelial growth factor (VEGF), the strongest known angiogenic cytokine and also a potent enhancer of vascular permeability, is closely associated with diabetic ocular complications and other intraocular neovascular diseases. The therapeutic effect of VEGF-neutralizing antibody on oxygen-induced retinopathy in an experimental murine model of proliferative retinopathy was investigated. Intraocular and systemic injection of the antibody resulted in 46% and 18% reductions in the number of nuclei of newly formed vessels of this model, respectively. The results demonstrated that a neutralizing antibody against VEGF was highly effective in the treatment of intraocular neovascularization and suggested possible modes of therapy in human intraocular neovascular diseases, including diabetic proliferative retinopathy.
Editor: Netherlands: Elsevier Inc
Idioma: Inglês

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Effects of intraocular or systemic administration of neutralizing antibody against vascular endothelial growth factor on the murine experimental model of retinopathy

Sone, Hirohito ; Kawakami, Yasushi ; Kumagai, Arno K. ; Okuda, Yukichi ; Sekine, Yasuo ; Honmura, Sachiko ; Segawa, Toshiaki ; Suzuki, Hideo ; Yamashita, Kamejiro ; Yamada, Nobuhiro

Netherlands: Elsevier Inc

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