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Dissolving Candlelit Microneedle for Chronic Inflammatory Skin Diseases

Ohn, Jungyoon ; Jang, Mingyu ; Kang, Bo Mi ; Yang, Huisuk ; Hong, Jin Tae ; Kim, Kyu Han ; Kwon, Ohsang ; Jung, Hyungil

Advanced science, 2021-07, Vol.8 (14), p.2004873-n/a [Periódico revisado por pares]

Germany: John Wiley & Sons, Inc

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Título:
Dissolving Candlelit Microneedle for Chronic Inflammatory Skin Diseases
Autor: Ohn, Jungyoon ; Jang, Mingyu ; Kang, Bo Mi ; Yang, Huisuk ; Hong, Jin Tae ; Kim, Kyu Han ; Kwon, Ohsang ; Jung, Hyungil
Assuntos: Administration, Cutaneous ; Animals ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - therapeutic use ; candlelit microneedles ; Chronic Disease ; chronic inflammatory skin diseases ; Dermatitis ; Disease Models, Animal ; dissolving microneedles ; Drug delivery systems ; Drug Delivery Systems - methods ; Female ; Inflammation - complications ; Inflammation - drug therapy ; Mice ; Mice, Inbred C57BL ; Needles ; Physical properties ; Psoriasis ; Skin ; Skin diseases ; Skin Diseases - complications ; Skin Diseases - drug therapy ; triamcinolone acetonide ; Triamcinolone Acetonide - administration & dosage ; Triamcinolone Acetonide - therapeutic use
É parte de: Advanced science, 2021-07, Vol.8 (14), p.2004873-n/a
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Chronic inflammatory skin diseases (CISDs) negatively impact a large number of patients. Injection of triamcinolone acetonide (TA), an anti‐inflammatory steroid drug, directly into the dermis of diseased skin using needle‐syringe systems is a long‐established procedure for treating recalcitrant lichenified lesions of CISDs, referred to as TA intralesional injection (TAILI). However, TAILI causes severe pain, causing patients to be stressed and reluctant to undergo treatment. Furthermore, the practitioner dependency on the amount and depth of the injected TA makes it difficult to predict the prognosis. Here, candle flame (“candlelit”)‐shaped TA‐loaded dissolving microneedles (Candlelit‐DMN) are designed and fabricated out of biocompatible and biodegradable molecules. Candlelit‐DMN distributes TA evenly across human skin tissue. Conjoined with the applicator, Candlelit‐DMN is efficiently inserted into human skin in a standardized manner, enabling TA to be delivered within the target layer. In an in vivo skin inflammation mouse model, Candlelit‐DMN inserted with the applicator effectively alleviates inflammation by suppressing inflammatory cell infiltration and cytokine gene expression, to the same extent as TAILI. This Candlelit‐DMN with the applicator arouses the interest of dermatologists, who prefer it to the current TAILI procedure. Candle flame‐shaped triamcinolone acetonide‐loaded dissolving microneedle is designed and fabricated, out of biocompatible molecules. With an applicator, the microneedles are efficiently inserted into human skin in a standardized manner without pain, enabling the drug to be delivered within the target layer. In an in vivo skin inflammation mouse model, the microneedles inserted with the applicator effectively alleviate inflammation.
Editor: Germany: John Wiley & Sons, Inc
Idioma: Inglês

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Dissolving Candlelit Microneedle for Chronic Inflammatory Skin Diseases

Ohn, Jungyoon ; Jang, Mingyu ; Kang, Bo Mi ; Yang, Huisuk ; Hong, Jin Tae ; Kim, Kyu Han ; Kwon, Ohsang ; Jung, Hyungil

Germany: John Wiley & Sons, Inc

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