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Dramatic response to encorafenib plus binimetinib in a patient with leukemoid reaction from metastatic melanoma.

Cerro, Marianna ; Maccallini, Maria Teresa ; Russillo, Michelangelo

Recenti progressi in medicina, 2024-05, Vol.115 (5), p.13e [Periódico revisado por pares]

Italy

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Título:
Dramatic response to encorafenib plus binimetinib in a patient with leukemoid reaction from metastatic melanoma.
Autor: Cerro, Marianna ; Maccallini, Maria Teresa ; Russillo, Michelangelo
Assuntos: Adult ; Antineoplastic Combined Chemotherapy Protocols - administration & dosage ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Benzimidazoles - administration & dosage ; Carbamates - administration & dosage ; Female ; Humans ; Melanoma - drug therapy ; Melanoma - genetics ; Melanoma - pathology ; Mutation ; Proto-Oncogene Proteins B-raf - genetics ; Skin Neoplasms - drug therapy ; Skin Neoplasms - genetics ; Skin Neoplasms - pathology ; Sulfonamides - administration & dosage ; Treatment Outcome
É parte de: Recenti progressi in medicina, 2024-05, Vol.115 (5), p.13e
Notas: ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
Descrição: Paraneoplastic leukemoid reaction (PLR) is an extremely rare condition in patients with melanoma and it is frequently associated with poor prognosis. BRAF gene mutational analysis represents the gold standard in patients with inoperable or metastatic melanoma as the possible presence of target mutations allows the use of the combination treatment with BRAF and MEK inhibitors. In this article, the case of a young woman with BRAF V600E mutated metastatic melanoma associated with PLR who received encorafenib and binimetinib is presented and discussed, with a focus on the relevant treatment response.
Editor: Italy
Idioma: Italiano

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Dramatic response to encorafenib plus binimetinib in a patient with leukemoid reaction from metastatic melanoma.

Cerro, Marianna ; Maccallini, Maria Teresa ; Russillo, Michelangelo

Italy

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