Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay

Hall, Justin ; Brault, Amy ; Vincent, Fabien ; Weng, Shawn ; Wang, Hong ; Dumlao, Darren ; Aulabaugh, Ann ; Aivazian, Dikran ; Castro, Dana ; Chen, Ming ; Culp, Jeffrey ; Dower, Ken ; Gardner, Joseph ; Hawrylik, Steven ; Golenbock, Douglas ; Hepworth, David ; Horn, Mark ; Jones, Lyn ; Jones, Peter ; Latz, Eicke ; Li, Jing ; Lin, Lih-Ling ; Lin, Wen ; Lin, David ; Lovering, Frank ; Niljanskul, Nootaree ; Nistler, Ryan ; Pierce, Betsy ; Plotnikova, Olga ; Schmitt, Daniel ; Shanker, Suman ; Smith, James ; Snyder, William ; Subashi, Timothy ; Trujillo, John ; Tyminski, Edyta ; Wang, Guoxing ; Wong, Jimson ; Lefker, Bruce ; Dakin, Leslie ; Leach, Karen Nakano, Hiroyasu

PloS one, 2017-09, Vol.12 (9), p.e0184843-e0184843 [Periódico revisado por pares]

United States: Public Library of Science

Texto completo disponível