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TISIDB: an integrated repository portal for tumor–immune system interactions

Ru, Beibei ; Wong, Ching Ngar ; Tong, Yin ; Zhong, Jia Yi ; Zhong, Sophia Shek Wa ; Wu, Wai Chung ; Chu, Ka Chi ; Wong, Choi Yiu ; Lau, Chit Ying ; Chen, Ian ; Chan, Nam Wai ; Zhang, Jiangwen Wren, Jonathan

Bioinformatics, 2019-10, Vol.35 (20), p.4200-4202 [Periódico revisado por pares]

England: Oxford University Press

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  • Título:
    TISIDB: an integrated repository portal for tumor–immune system interactions
  • Autor: Ru, Beibei ; Wong, Ching Ngar ; Tong, Yin ; Zhong, Jia Yi ; Zhong, Sophia Shek Wa ; Wu, Wai Chung ; Chu, Ka Chi ; Wong, Choi Yiu ; Lau, Chit Ying ; Chen, Ian ; Chan, Nam Wai ; Zhang, Jiangwen
  • Wren, Jonathan
  • É parte de: Bioinformatics, 2019-10, Vol.35 (20), p.4200-4202
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Abstract Summary The interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor–immune interactions, we have designed a user-friendly web portal TISIDB, which integrated multiple types of data resources in oncoimmunology. First, we manually curated 4176 records from 2530 publications, which reported 988 genes related to anti-tumor immunity. Second, genes associated with the resistance or sensitivity of tumor cells to T cell-mediated killing and immunotherapy were identified by analyzing high-throughput screening and genomic profiling data. Third, associations between any gene and immune features, such as lymphocytes, immunomodulators and chemokines, were pre-calculated for 30 TCGA cancer types. In TISIDB, biologists can cross-check a gene of interest about its role in tumor–immune interactions through literature mining and high-throughput data analysis, and generate testable hypotheses and high quality figures for publication. Availability and implementation http://cis.hku.hk/TISIDB Supplementary information Supplementary data are available at Bioinformatics online.
  • Editor: England: Oxford University Press
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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