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HOPE in action: A prospective multicenter pilot study of liver transplantation from donors with HIV to recipients with HIV

Florman, Sander ; Motter, Jennifer D. ; Brown, Diane ; Ostrander, Darin ; Liang, Tao ; Werbel, William A. ; Cameron, Andrew ; Ottmann, Shane ; Hamilton, James P. ; Bowring, Mary G. ; Fernandez, Reinaldo E. ; Doby, Brianna ; Labo, Nazzarena ; Miley, Wendell ; Price, Jennifer C. ; Stock, Peter ; Kirchner, Varvara A. ; Elias, Nahel ; Wolfe, Cameron ; Quinn, Thomas C. ; Odim, Jonah ; Morsheimer, Megan ; Mehta, Sapna A. ; Rana, Meenakshi M. ; Huprikar, Shirish ; Massie, Allan ; Segev, Dorry L. ; Edwards, Carolyn ; Ranganna, Karthik M ; Pearson, Thomas ; Mehta, Aneesh K ; Lyon, G. Marshall ; Huckaby, Jeryl ; Elbein, Rivka ; Ferry, Elizabeth ; Adebiyi, Margaret ; Adebiyi, Oluwafisayo ; Kubal, Chandrahekhar ; Ambinder, Richard ; Barnaba, Brittany ; Bollinger, Juli ; Boyarsky, Brian ; Desai, Niraj N ; Doby, Brianna ; Johnstone, Jaylyn ; Kirby, Charles ; Klock, Ethan ; Kusemiju, Oyinkansola ; Schmidt, Haley ; Seaman, Shanti ; Thomas, Margret ; Akhran, Aleya ; Coakley, Margaret ; Cooper, Matthew ; Stucke, Alyssa ; Castillo‐Lugo, Jose A ; Townsend, Melba ; Haydel, Brandy M. ; Dieter, Rebecca ; Deterville, Cecilia ; Klein, Elizabeth ; Neumann, Henry ; Weldon, Elaina P ; Hand, Jonathan ; Smith, Angela R ; Blumberg, Emily A ; Donaghy, Eileen ; Dunn, Ty ; Sawinski, Deirdre ; Santos, Carlos A. Q ; Mehta, Shikha ; Mompoint‐Williams, Darnell ; Gadzhyan, Janette ; Aslam, Saima ; Chao, Ada ; Rogers, Rodney ; Apewokin, Senu ; Harrison, Kathleen ; Kramer, Samantha ; Wilkinson, Rachel ; Benamu, Esther ; Spaggiari, Mario ; Bruno, Kelly ; Jeffery, Alicia ; Marrazzo, Ilise D ; Morris, Michele I ; Munoz, Carlos ; Simkins, Jacques ; Hughes Kramer, Kailey ; Pakstis, Diana Lynn ; Silveira, Fernanda ; Baah, Whitney ; Carlson, Emily ; La Hoz, Ricardo M ; Agarwal, Avinash ; Baldecchi, Mary ; Brigle, Nathaniel ; Butkus‐Small, Catherine ; Malinis, Maricar ; Tomlin, Ricarda

American journal of transplantation, 2022-03, Vol.22 (3), p.853-864 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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Título:
HOPE in action: A prospective multicenter pilot study of liver transplantation from donors with HIV to recipients with HIV
Autor: Florman, Sander ; Motter, Jennifer D. ; Brown, Diane ; Ostrander, Darin ; Liang, Tao ; Werbel, William A. ; Cameron, Andrew ; Ottmann, Shane ; Hamilton, James P. ; Bowring, Mary G. ; Fernandez, Reinaldo E. ; Doby, Brianna ; Labo, Nazzarena ; Miley, Wendell ; Price, Jennifer C. ; Stock, Peter ; Kirchner, Varvara A. ; Elias, Nahel ; Wolfe, Cameron ; Quinn, Thomas C. ; Odim, Jonah ; Morsheimer, Megan ; Mehta, Sapna A. ; Rana, Meenakshi M. ; Huprikar, Shirish ; Massie, Allan ; Segev, Dorry L. ; Edwards, Carolyn ; Ranganna, Karthik M ; Pearson, Thomas ; Mehta, Aneesh K ; Lyon, G. Marshall ; Huckaby, Jeryl ; Elbein, Rivka ; Ferry, Elizabeth ; Adebiyi, Margaret ; Adebiyi, Oluwafisayo ; Kubal, Chandrahekhar ; Ambinder, Richard ; Barnaba, Brittany ; Bollinger, Juli ; Boyarsky, Brian ; Desai, Niraj N ; Doby, Brianna ; Johnstone, Jaylyn ; Kirby, Charles ; Klock, Ethan ; Kusemiju, Oyinkansola ; Schmidt, Haley ; Seaman, Shanti ; Thomas, Margret ; Akhran, Aleya ; Coakley, Margaret ; Cooper, Matthew ; Stucke, Alyssa ; Castillo‐Lugo, Jose A ; Townsend, Melba ; Haydel, Brandy M. ; Dieter, Rebecca ; Deterville, Cecilia ; Klein, Elizabeth ; Neumann, Henry ; Weldon, Elaina P ; Hand, Jonathan ; Smith, Angela R ; Blumberg, Emily A ; Donaghy, Eileen ; Dunn, Ty ; Sawinski, Deirdre ; Santos, Carlos A. Q ; Mehta, Shikha ; Mompoint‐Williams, Darnell ; Gadzhyan, Janette ; Aslam, Saima ; Chao, Ada ; Rogers, Rodney ; Apewokin, Senu ; Harrison, Kathleen ; Kramer, Samantha ; Wilkinson, Rachel ; Benamu, Esther ; Spaggiari, Mario ; Bruno, Kelly ; Jeffery, Alicia ; Marrazzo, Ilise D ; Morris, Michele I ; Munoz, Carlos ; Simkins, Jacques ; Hughes Kramer, Kailey ; Pakstis, Diana Lynn ; Silveira, Fernanda ; Baah, Whitney ; Carlson, Emily ; La Hoz, Ricardo M ; Agarwal, Avinash ; Baldecchi, Mary ; Brigle, Nathaniel ; Butkus‐Small, Catherine ; Malinis, Maricar ; Tomlin, Ricarda
Assuntos: Acquired immune deficiency syndrome ; AIDS ; Antiretroviral drugs ; Antiretroviral therapy ; Case reports ; CD4 antigen ; clinical research/practice ; Donors ; ethics and public policy ; Follow-Up Studies ; Graft rejection ; Graft Survival ; Graft-versus-host reaction ; Hepatitis ; Hepatitis C ; HIV ; HIV Infections - complications ; Human immunodeficiency virus ; Humans ; infection and infectious agents ‐ viral: hepatitis C ; infection and infectious agents ‐ viral: human herpesvirus 8 (HHV‐8) ; infection and infectious agents ‐ viral: human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) ; Infections ; infectious disease ; liver disease ; liver disease: infectious ; Liver diseases ; Liver transplantation ; Liver Transplantation - adverse effects ; liver transplantation/hepatology ; Liver transplants ; Medical ethics ; Patients ; Pilot Projects ; Prospective Studies ; Tissue Donors
É parte de: American journal of transplantation, 2022-03, Vol.22 (3), p.853-864
Notas: Funding information
Christine M. Durand, Sander Florman, Aaron A.R. Tobian, and Dorry L. Segev contributed equally.
This work was supported by the by National Institute of Allergy and Infectious Diseases grant numbers 1P30AI094189 (Johns Hopkins Center for AIDS Research), 1R01AI120938 (Tobian), U01AI138897 (Durand/Segev), and U01AI134591 (Durand/Segev) and in part by the Division of Intramural Research, NIAID, NIH (Quinn and Redd), and the Regional Oncology Research Center, 3P30CA006973 NCI/NIH (Nelson) and with federal funds from the National Cancer Institute, National Institutes of Health under Contract No. HHSN261200800001E and Contract No. 75N91019D00024 (Whitby). The analyses described here are the responsibility of the authors alone and do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products or organizations imply endorsement by the U.S. Government.
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Authors contributed equally
Statistical analysis: Motter, Bowring, Liang, Yu, Massie.
Administrative, technical, or material support: Ostrander, Doby, Eby, Fernandez
Authorship Contributions
Critical revision of the manuscript for important intellectual content: All authors.
Durand, Motter, Brown and Massie had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. All authors vouch for the accuracy and completeness of the data and for the fidelity of the study to the protocol.
Concept and design: Durand, Brown, Bowring, Motter, Hamilton, Redd, Ostrander, Massie, Tobian, Segev.
Acquisition, analysis, or interpretation of data: Durand, Brown, Bowring, Liang Motter, Yu, Werbel, Cameron, Ottmann, Hamilton, Massie, Doby, Eby, Fernandez, Friedman-Moraco, Price, Chin-Hong, Pruett, Kirchner, Wojciechowski, Elias, Mehta, Stosor, Wolfe, Mehta, Rana, Florman, Huprikar, Massie, Werbel, Tobian, Segev, Labo, Miley, Whitby.
Drafting of the manuscript: Durand, Motter, Massie, Segev, Tobian, Werbel.
Obtained funding: Durand, Redd, Tobian, Segev.
Descrição: Liver transplantation (LT) from donors‐with‐HIV to recipients‐with‐HIV (HIV D+/R+) is permitted under the HOPE Act. There are only three international single‐case reports of HIV D+/R+ LT, each with limited follow‐up. We performed a prospective multicenter pilot study comparing HIV D+/R+ to donors‐without‐HIV to recipients‐with‐HIV (HIV D−/R+) LT. We quantified patient survival, graft survival, rejection, serious adverse events (SAEs), human immunodeficiency virus (HIV) breakthrough, infections, and malignancies, using Cox and negative binomial regression with inverse probability of treatment weighting. Between March 2016–July 2019, there were 45 LTs (8 simultaneous liver‐kidney) at 9 centers: 24 HIV D+/R+, 21 HIV D−/R+ (10 D− were false‐positive). The median follow‐up time was 23 months. Median recipient CD4 was 287 cells/µL with 100% on antiretroviral therapy; 56% were hepatitis C virus (HCV)‐seropositive, 13% HCV‐viremic. Weighted 1‐year survival was 83.3% versus 100.0% in D+ versus D− groups (p = .04). There were no differences in one‐year graft survival (96.0% vs. 100.0%), rejection (10.8% vs. 18.2%), HIV breakthrough (8% vs. 10%), or SAEs (all p > .05). HIV D+/R+ had more opportunistic infections, infectious hospitalizations, and cancer. In this multicenter pilot study of HIV D+/R+ LT, patient and graft survival were better than historical cohorts, however, a potential increase in infections and cancer merits further investigation. A multicenter study of HIV+ donor to HIV+ recipient liver transplantation under the HOPE Act shows that patient and graft survival were better than historical cohorts, but the possible increased incidence of infections and cancer merits further investigation.
Editor: United States: Wiley Subscription Services, Inc
Idioma: Inglês

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HOPE in action: A prospective multicenter pilot study of liver transplantation from donors with HIV to recipients with HIV

United States: Wiley Subscription Services, Inc

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