skip to main content
Idioma:

Effect of sexual steroids on the calcium content of aortic atherosclerotic plaque of oophorectomized rabbits

José Mendes Aldrighi José Ramón Lanz; A P Mansur; Tania Leme da Rocha Martinez; José Antônio Franchini Ramires

Brazilian journal of medical and biological research Ribeirão Preto v. 38, n. 5, p. 705-711, maio 2005

Ribeirão Preto 2005

Item não circula. Consulte sua biblioteca.(Acessar)

  • Título:
    Effect of sexual steroids on the calcium content of aortic atherosclerotic plaque of oophorectomized rabbits
  • Autor: José Mendes Aldrighi
  • José Ramón Lanz; A P Mansur; Tania Leme da Rocha Martinez; José Antônio Franchini Ramires
  • Assuntos: ESTRÓGENOS (FARMACOLOGIA); HORMÔNIOS PROGESTACIONAIS (FARMACOLOGIA); CÁLCIO; ARTERIOSCLEROSE (QUIMIOTERAPIA); AORTA
  • É parte de: Brazilian journal of medical and biological research Ribeirão Preto v. 38, n. 5, p. 705-711, maio 2005
  • Descrição: We determined the effect of conjugated equine estrogen plus medroxyprogesterone acetate on calcium content of aortic atherosclerotic lesions in oophorectomized adult New Zealand rabbits submitted to a cholesterol rich diet. Five groups of 10 animals each were studied: G1 = control, G2 = cholesterol diet only, G3 = diet plus conjugated equine estrogen (0.625 mg/day); G4 and G5 = diet, conjugated equine estrogen (0.625 mg/day) plus medroxyprogesterone acetate (5 and 10 mg/day, respectively). Mean weight varied from 2.7 n 0.27 to 3.1 n 0.20 kg (P = 0.38) between groups at the beginning and 3.1 n 0.27 to 3.5 n 0.20 kg (P = 0.35) at the end of the experiment. Cholesterol and triglyceride levels were determined at the time of oophorectomy, 21 days after surgery (time 0), and at the end of follow-up of 90 days. The planimetric method was used to measure plaque and caryometric method for histopathologic examination of the aorta. Calcium content was determined by the method of von Kossa. A similar increase in cholesterol occurred in all treated groups without differences between them at the end of the study. Groups G4 and G5 had smaller areas of atherosclerotic lesions (2.33 n 2.8 and 2.45 n 2.1 cmy, respectively) than the groups receiving no progestogens (G2: 5.6 n 4 and G3: 4.6 n 2.8 cmy; P = 0.02). The relation between lesion area and total aorta area was smaller in groups treated with combined drugs compared to the groups receiving no progesterone (G4: 14.9 n
    13 and G5: 14.2 n 13.4 vs G2: 35.8 n 26 and G3: 25 n 8 cmy, respectively; P = 0.017). Oral conjugated equine estrogen (0.625 mg/day) plus medroxyprogesterone acetate (5 or 10 mg/day) provoked a greater reduction in atherosclerotic plaque area and calcium content in treated groups, suggesting a dose-dependent effect
  • Editor: Ribeirão Preto
  • Data de criação/publicação: 2005
  • Formato: p. 705-711.
  • Idioma: Inglês
Links
Voltar para lista de resultados
Ir para página anteriorAnterior Resultado  4 AvançarIr para próxima página

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.