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Renin-Angiotensin System in Huntington′s Disease: Evidence from Animal Models and Human Patients

Kangussu, Lucas M. ; Rocha, Natalia P. ; Valadão, Priscila A. C. ; Machado, Thatiane C. G. ; Soares, Kívia B. ; Joviano-Santos, Julliane V. ; Latham, Leigh B. ; Colpo, Gabriela D. ; Almeida-Santos, Ana Flávia ; Furr Stimming, Erin ; Simões e Silva, Ana Cristina ; Teixeira, Antônio L. ; Miranda, Aline Silva ; Guatimosim, Cristina

International journal of molecular sciences, 2022-07, Vol.23 (14), p.7686 [Periódico revisado por pares]

Basel: MDPI AG

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Título:
Renin-Angiotensin System in Huntington′s Disease: Evidence from Animal Models and Human Patients
Autor: Kangussu, Lucas M. ; Rocha, Natalia P. ; Valadão, Priscila A. C. ; Machado, Thatiane C. G. ; Soares, Kívia B. ; Joviano-Santos, Julliane V. ; Latham, Leigh B. ; Colpo, Gabriela D. ; Almeida-Santos, Ana Flávia ; Furr Stimming, Erin ; Simões e Silva, Ana Cristina ; Teixeira, Antônio L. ; Miranda, Aline Silva ; Guatimosim, Cristina
Assuntos: Alzheimer's disease ; Angiotensin ; Angiotensin II ; angiotensin peptides ; Animal cognition ; Animal models ; BACHD ; Blood pressure ; Central nervous system ; Endocrine system ; Gene expression ; Huntington's disease ; Investigations ; Motor task performance ; Muscle strength ; Neostriatum ; Pathophysiology ; Patients ; Peptides ; Plasma ; Plasma levels ; Prefrontal cortex ; Proteins ; Renin ; renin-angiotensin system
É parte de: International journal of molecular sciences, 2022-07, Vol.23 (14), p.7686
Descrição: The Renin-Angiotensin System (RAS) is expressed in the central nervous system and has important functions that go beyond blood pressure regulation. Clinical and experimental studies have suggested that alterations in the brain RAS contribute to the development and progression of neurodegenerative diseases. However, there is limited information regarding the involvement of RAS components in Huntington’s disease (HD). Herein, we used the HD murine model, (BACHD), as well as samples from patients with HD to investigate the role of both the classical and alternative axes of RAS in HD pathophysiology. BACHD mice displayed worse motor performance in different behavioral tests alongside a decrease in the levels and activity of the components of the RAS alternative axis ACE2, Ang-(1-7), and Mas receptors in the striatum, prefrontal cortex, and hippocampus. BACHD mice also displayed a significant increase in mRNA expression of the AT1 receptor, a component of the RAS classical arm, in these key brain regions. Moreover, patients with manifest HD presented higher plasma levels of Ang-(1-7). No significant changes were found in the levels of ACE, ACE2, and Ang II. Our findings provided the first evidence that an imbalance in the RAS classical and counter-regulatory arms may play a role in HD pathophysiology.
Editor: Basel: MDPI AG
Idioma: Inglês

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Renin-Angiotensin System in Huntington′s Disease: Evidence from Animal Models and Human Patients

Basel: MDPI AG

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