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Inhibition of adenosine deaminase activity of aortic endothelial cells by selected flavonoids

Melzig, M. F.

Planta medica, 1996-02, Vol.62 (1), p.20-21 [Periódico revisado por pares]

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Título:
Inhibition of adenosine deaminase activity of aortic endothelial cells by selected flavonoids
Autor: Melzig, M. F.
Assuntos: adenosina ; adenosine ; Adenosine Deaminase Inhibitors ; Animals ; Aorta - cytology ; Aorta - drug effects ; Aorta - enzymology ; Biological and medical sciences ; Cattle ; deamination ; desaminacion ; desamination ; drug plants ; Endothelium, Vascular - cytology ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - enzymology ; farmacologia ; flavonoide ; flavonoides ; flavonoids ; Flavonoids - chemistry ; Flavonoids - pharmacology ; General pharmacology ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; pharmacologie ; pharmacology ; Pharmacology. Drug treatments ; plantas medicinales ; plante medicinale ; Structure-Activity Relationship
É parte de: Planta medica, 1996-02, Vol.62 (1), p.20-21
Notas: F60
F
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Flavonols like quercetin, myricetin, and kaempferol inhibit the activity of the adenosine deaminase of endothelial cells (IC50 between 26 and 32 micro mol/l), while flavones are inactive. These results support the suggestion that many pharmacological actions of flavonoids are mediated by an amplification of the effect of endogenous adenosine via adenosine receptors because adenosine deaminase is responsible for the adenosine inactivation.
Editor: Stuttgart: Thieme
Idioma: Inglês

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