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Time Course of the Phenotype of Blood and Bone Marrow Monocytes and Macrophages in the Lung after Cigarette Smoke Exposure In Vivo

Oliveira da Silva, Camila ; Monte-Alto-Costa, Andréa ; Renovato-Martins, Mariana ; Viana Nascimento, Filipe Jorge ; Dos Santos Valença, Samuel ; Lagente, Vincent ; Pôrto, Luís Cristóvão ; Victoni, Tatiana

International journal of molecular sciences, 2017-09, Vol.18 (9), p.1940 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Time Course of the Phenotype of Blood and Bone Marrow Monocytes and Macrophages in the Lung after Cigarette Smoke Exposure In Vivo
Autor: Oliveira da Silva, Camila ; Monte-Alto-Costa, Andréa ; Renovato-Martins, Mariana ; Viana Nascimento, Filipe Jorge ; Dos Santos Valença, Samuel ; Lagente, Vincent ; Pôrto, Luís Cristóvão ; Victoni, Tatiana
Assuntos: Animals ; Blood ; Bone marrow ; Cancer ; Chronic obstructive pulmonary disease ; Cigarette smoke ; COPD ; Endocrinology and metabolism ; Exposure ; Food and Nutrition ; Human health and pathology ; Interleukin-6 - genetics ; Interleukin-6 - metabolism ; Lectins, C-Type - genetics ; Lectins, C-Type - metabolism ; Leukocytes (neutrophilic) ; Life Sciences ; Lung - metabolism ; Lung - pathology ; Lung diseases ; Macrophages ; Macrophages - metabolism ; Male ; Mannose-Binding Lectins - genetics ; Mannose-Binding Lectins - metabolism ; Matrix metalloproteinase ; Matrix Metalloproteinase 12 - genetics ; Matrix Metalloproteinase 12 - metabolism ; Metalloproteinase ; Mice ; Mice, Inbred C57BL ; Monocytes ; Monocytes - metabolism ; Nitric oxide ; Nitric Oxide - metabolism ; Obstructive lung disease ; Pathogenesis ; Phenotype ; Pulmonary Disease, Chronic Obstructive - etiology ; Receptors, Cell Surface - genetics ; Receptors, Cell Surface - metabolism ; Recruitment ; Smoke ; Tobacco Smoke Pollution - adverse effects ; Transforming growth factor ; Transforming Growth Factor beta - genetics ; Transforming Growth Factor beta - metabolism ; Transforming growth factor-b ; Tumor Necrosis Factor-alpha - genetics ; Tumor Necrosis Factor-alpha - metabolism ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α
É parte de: International journal of molecular sciences, 2017-09, Vol.18 (9), p.1940
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMCID: PMC5618589
These authors contributed equally to this work.
Descrição: Alveolar macrophages play a central role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Monocytes are recruited from blood during inflammation and then mature into alveolar macrophages. The aim of this study was to investigate the effect of cigarette smoke (CS) at different times in lung macrophages and monocytes from blood and bone marrow in mice. Male mice (C57BL/6, = 45) were divided into groups: control, CS 5 days, CS 14 days and CS 30 days. Five days' CS exposure induced a pronounced influx of neutrophils and macrophages in the lung associated with increased levels of keratinocyte chemoattractant (KC), tumor necrosis factor-α (TNF-α), nitric oxide (NO) and matrix metalloproteinase (MMP)-12. After 14 days of CS exposure, neutrophil recruitment and cytokine production were greatly reduced. Moreover, chronic CS exposure led to increased recruitment of macrophages (with high expression of CD206), transforming growth factor-β (TGF-β) production as well as no detection of TNF-α, interleukin (IL)-6 and KC. CS can also change the monocyte phenotype in the blood and bone marrow, with an increase in Ly6C cells. These results show for the first time that CS can change not only macrophage polarization but also monocyte. These results suggest that continued recruitment of Ly6C monocytes may help the distinct renewing macrophage M2 population required for COPD progression.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Time Course of the Phenotype of Blood and Bone Marrow Monocytes and Macrophages in the Lung after Cigarette Smoke Exposure In Vivo

Oliveira da Silva, Camila ; Monte-Alto-Costa, Andréa ; Renovato-Martins, Mariana ; Viana Nascimento, Filipe Jorge ; Dos Santos Valença, Samuel ; Lagente, Vincent ; Pôrto, Luís Cristóvão ; Victoni, Tatiana

Switzerland: MDPI AG

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