Idioma:

Pharmacokinetics/Pharmacodynamics Evaluation of Flomoxef against Extended-Spectrum Beta-Lactamase-Producing Escherichia coli In Vitro and In Vivo in a Murine Thigh Infection Model

Tashiro, Sho ; Hayashi, Marina ; Takemura, Wataru ; Igarashi, Yuki ; Liu, Xiaoxi ; Mizukami, Yuki ; Kojima, Nana ; Enoki, Yuki ; Taguchi, Kazuaki ; Yokoyama, Yuta ; Nakamura, Tomonori ; Matsumoto, Kazuaki

Pharmaceutical research, 2021, Vol.38 (1), p.27-35 [Periódico revisado por pares]

New York: Springer US

Texto completo disponível

Citações Citado por

Enviar para

Título:
Pharmacokinetics/Pharmacodynamics Evaluation of Flomoxef against Extended-Spectrum Beta-Lactamase-Producing Escherichia coli In Vitro and In Vivo in a Murine Thigh Infection Model
Autor: Tashiro, Sho ; Hayashi, Marina ; Takemura, Wataru ; Igarashi, Yuki ; Liu, Xiaoxi ; Mizukami, Yuki ; Kojima, Nana ; Enoki, Yuki ; Taguchi, Kazuaki ; Yokoyama, Yuta ; Nakamura, Tomonori ; Matsumoto, Kazuaki
Assuntos: Antibacterial activity ; Antibacterial agents ; Bactericidal activity ; Beta lactamases ; Biochemistry ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; E coli ; Escherichia coli ; Flomoxef ; Health aspects ; Infection ; Medical Law ; Minimum inhibitory concentration ; Neutropenia ; Pharmacodynamics ; Pharmacokinetics ; Pharmacology/Toxicology ; Pharmacy ; Research Paper ; β Lactamase
É parte de: Pharmaceutical research, 2021, Vol.38 (1), p.27-35
Descrição: Purpose Although flomoxef (FMOX) has attracted substantial attention as an antibiotic against extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-producing E. coli ), the pharmacokinetics/pharmacodynamics (PK/PD) characteristics of FMOX against ESBL-producing E. coli is unclear. The aim of this study was to determine the PK/PD index of FMOX against ESBL-producing E. coli . Methods In vitro time-kill curve studies and in vivo PK/PD experiments were carried out. Results Time–kill curves exhibited a unique bactericidal activity: time-dependent activity at low concentrations and concentration-dependent activity at high concentrations. In neutropenic murine thigh infection experiments, the antibacterial activity of FMOX correlated with the time that the free drug concentration remaining above the minimum inhibitory concentration (MIC) ( f T>MIC) and the ratio of the area under the free drug concentration–time curve for a 24 h period to the MIC ( f AUC 24 /MIC). However, the burden of ESBL producing E. coli significantly reduced when the time intervals for administration were shorter among three dosage regimens with same magnitude of f AUC 24 /MIC, indicating that f T>MIC is significant PK/PD index. The target value of f T>MIC for 1 log 10 kill reduction was 35.1%. Conclusions f T>MIC is the most significant PK/PD index of FMOX against ESBL-producing E. coli and its target value is ≥ 40%.
Editor: New York: Springer US
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 6 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Pharmacokinetics/Pharmacodynamics Evaluation of Flomoxef against Extended-Spectrum Beta-Lactamase-Producing Escherichia coli In Vitro and In Vivo in a Murine Thigh Infection Model

Tashiro, Sho ; Hayashi, Marina ; Takemura, Wataru ; Igarashi, Yuki ; Liu, Xiaoxi ; Mizukami, Yuki ; Kojima, Nana ; Enoki, Yuki ; Taguchi, Kazuaki ; Yokoyama, Yuta ; Nakamura, Tomonori ; Matsumoto, Kazuaki

New York: Springer US

Buscando em bases de dados remotas. Favor aguardar.