Idioma:

Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice

Colaianni, Graziana ; Mongelli, Teresa ; Cuscito, Concetta ; Pignataro, Paolo ; Lippo, Luciana ; Spiro, Giovanna ; Notarnicola, Angela ; Severi, Ilenia ; Passeri, Giovanni ; Mori, Giorgio ; Brunetti, Giacomina ; Moretti, Biagio ; Tarantino, Umberto ; Colucci, Silvia C ; Reseland, Janne E ; Vettor, Roberto ; Cinti, Saverio ; Grano, Maria

Scientific reports, 2017-06, Vol.7 (1), p.2811-16, Article 2811 [Periódico revisado por pares]

England: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice
Autor: Colaianni, Graziana ; Mongelli, Teresa ; Cuscito, Concetta ; Pignataro, Paolo ; Lippo, Luciana ; Spiro, Giovanna ; Notarnicola, Angela ; Severi, Ilenia ; Passeri, Giovanni ; Mori, Giorgio ; Brunetti, Giacomina ; Moretti, Biagio ; Tarantino, Umberto ; Colucci, Silvia C ; Reseland, Janne E ; Vettor, Roberto ; Cinti, Saverio ; Grano, Maria
Assuntos: Animals ; Astronauts ; Atrophy ; Biopsy ; Bone density ; Bone Density - drug effects ; Bone Diseases, Metabolic - drug therapy ; Bone Diseases, Metabolic - genetics ; Bone Diseases, Metabolic - physiopathology ; Bone loss ; Bone mass ; Bone mineral density ; Cancellous bone ; Computed tomography ; Cortical bone ; Exercise ; Femur - drug effects ; Femur - physiopathology ; Fibronectins - administration & dosage ; Fibronectins - genetics ; Fractures ; Geriatrics ; Hindlimb Suspension - physiology ; Humans ; Lower Extremity - physiopathology ; Medicine ; Mice ; Microgravity ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - physiopathology ; Muscular Atrophy - drug therapy ; Muscular Atrophy - genetics ; Muscular Atrophy - physiopathology ; Musculoskeletal system ; Myosin ; Osteoporosis ; Physical Conditioning, Animal ; Recombinant Proteins - administration & dosage ; Recombinant Proteins - genetics ; Skeletal muscle
É parte de: Scientific reports, 2017-06, Vol.7 (1), p.2811-16, Article 2811
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: We previously showed that Irisin, a myokine released from skeletal muscle after physical exercise, plays a central role in the control of bone mass. Here we report that treatment with recombinant Irisin prevented bone loss in hind-limb suspended mice when administered during suspension (preventive protocol) and induced recovery of bone mass when mice were injected after bone loss due to a suspension period of 4 weeks (curative protocol). MicroCT analysis of femurs showed that r-Irisin preserved both cortical and trabecular bone mineral density, and prevented a dramatic decrease of the trabecular bone volume fraction. Moreover, r-Irisin protected against muscle mass decline in the hind-limb suspended mice, and maintained the fiber cross-sectional area. Notably, the decrease of myosin type II expression in unloaded mice was completely prevented by r-Irisin administration. Our data reveal for the first time that Irisin retrieves disuse-induced bone loss and muscle atrophy. These findings may lead to development of an Irisin-based therapy for elderly immobile osteoporotic and physically disable patients, and might represent a countermeasure for astronauts subjected to microgravity-induced bone and muscle losses.
Editor: England: Nature Publishing Group
Idioma: Inglês;Norueguês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 9 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice

England: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.