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Expression Cloning of an Adenylate Cyclase-Coupled Calcitonin Receptor

Lin, Herbert Y. ; Harris, Tonja L. ; Flannery, Merilee S. ; Aruffo, Alejandro ; Kaji, Eugene H. ; Gorn, Alan ; Kolakowski, Lee F. ; Lodish, Harvey F. ; Goldring, Steven R.

Science (American Association for the Advancement of Science), 1991-11, Vol.254 (5034), p.1022-1024 [Periódico revisado por pares]

United States: American Society for the Advancement of Science

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Título:
Expression Cloning of an Adenylate Cyclase-Coupled Calcitonin Receptor
Autor: Lin, Herbert Y. ; Harris, Tonja L. ; Flannery, Merilee S. ; Aruffo, Alejandro ; Kaji, Eugene H. ; Gorn, Alan ; Kolakowski, Lee F. ; Lodish, Harvey F. ; Goldring, Steven R.
Assuntos: Adenylyl Cyclases - physiology ; Amino Acid Sequence ; Animals ; Blotting, Northern ; Calcitonin ; Calcitonin - metabolism ; Cellular biology ; Cloning ; Cloning, Molecular ; Cyclic AMP - physiology ; Deoxyribonucleic acid ; DNA ; DNA - genetics ; Gene Expression ; genes ; Genetics ; Hormone receptors ; Hormones ; Kidney - physiology ; Molecular Sequence Data ; Proteins ; Receptors, Calcitonin ; Receptors, Cell Surface - genetics ; RNA, Messenger - genetics ; Swine
É parte de: Science (American Association for the Advancement of Science), 1991-11, Vol.254 (5034), p.1022-1024
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: A calcitonin receptor complementary DNA (cDNA) was cloned by expression of a cDNA library from a porcine kidney epithelial cell line in COS cells. The 482-amino acid receptor has high affinity for salmon calcitonin (dissociation constant K$_d$ ≈ 6 nM) and is functionally coupled to increases in intracellular cyclic adenosine monophosphate (cAMP). The receptor shows no sequence similarity to other reported G protein-coupled receptors but is homologous to the parathyroid hormone-parathyroid hormone-related peptide (PTH-PTHrP) receptor, indicating that the receptors for these hormones, which regulate calcium homeostasis, represent a new family of G protein-coupled receptors.
Editor: United States: American Society for the Advancement of Science
Idioma: Latim;Inglês

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Expression Cloning of an Adenylate Cyclase-Coupled Calcitonin Receptor

Lin, Herbert Y. ; Harris, Tonja L. ; Flannery, Merilee S. ; Aruffo, Alejandro ; Kaji, Eugene H. ; Gorn, Alan ; Kolakowski, Lee F. ; Lodish, Harvey F. ; Goldring, Steven R.

United States: American Society for the Advancement of Science

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