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Pseudomonas aeruginosa virulence genes identified in a Dictyostelium host model

Alibaud, Laeticia ; Köhler, Thilo ; Coudray, Alice ; Prigent-Combaret, Claire ; Bergeret, Evelyne ; Perrin, Jackie ; Benghezal, Mohammed ; Reimmann, Cornelia ; Gauthier, Yves ; van Delden, Christian ; Attree, Ina ; Fauvarque, Marie-Odile ; Cosson, Pierre

Cellular microbiology, 2008-03, Vol.10 (3), p.729-740 [Periódico revisado por pares]

Oxford, UK: Oxford, UK : Blackwell Publishing Ltd

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Título:
Pseudomonas aeruginosa virulence genes identified in a Dictyostelium host model
Autor: Alibaud, Laeticia ; Köhler, Thilo ; Coudray, Alice ; Prigent-Combaret, Claire ; Bergeret, Evelyne ; Perrin, Jackie ; Benghezal, Mohammed ; Reimmann, Cornelia ; Gauthier, Yves ; van Delden, Christian ; Attree, Ina ; Fauvarque, Marie-Odile ; Cosson, Pierre
Assuntos: Animals ; ATP-Binding Cassette Transporters ; ATP-Binding Cassette Transporters - genetics ; ATP-Binding Cassette Transporters - physiology ; Bacterial Proteins ; Bacterial Proteins - genetics ; Bacterial Proteins - physiology ; Bacteriology ; Dictyostelium ; Dictyostelium - microbiology ; DNA Transposable Elements ; Drosophila ; Female ; Humans ; Life Sciences ; Male ; Mice ; Microbiology and Parasitology ; Mutagenesis, Insertional ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - genetics ; Pseudomonas aeruginosa - pathogenicity ; Pseudomonas Infections ; Pseudomonas Infections - microbiology ; Survival Analysis ; Virulence ; Virulence - genetics ; Virulence Factors ; Virulence Factors - genetics
É parte de: Cellular microbiology, 2008-03, Vol.10 (3), p.729-740
Notas: http://dx.doi.org/10.1111/j.1462-5822.2007.01080.x
Descrição: The human pathogen Pseudomonas aeruginosa has been shown previously to use similar virulence factors when infecting mammalian hosts or Dictyostelium amoebae. Here we randomly mutagenized a clinical isolate of P. aeruginosa, and identified mutants with attenuated virulence towards Dictyostelium. These mutant strains also exhibited a strong decrease in virulence when infecting Drosophila and mice, confirming that P. aeruginosa makes use of similar virulence traits to confront these very different hosts. Further characterization of these bacterial mutants showed that TrpD is important for the induction of the quorum-sensing circuit, while PchH and PchI are involved in the induction of the type III secretion system. These results demonstrate the usefulness and the relevance of the Dictyostelium host model to identify and analyse new virulence genes in P. aeruginosa.
Editor: Oxford, UK: Oxford, UK : Blackwell Publishing Ltd
Idioma: Inglês

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Pseudomonas aeruginosa virulence genes identified in a Dictyostelium host model

Alibaud, Laeticia ; Köhler, Thilo ; Coudray, Alice ; Prigent-Combaret, Claire ; Bergeret, Evelyne ; Perrin, Jackie ; Benghezal, Mohammed ; Reimmann, Cornelia ; Gauthier, Yves ; van Delden, Christian ; Attree, Ina ; Fauvarque, Marie-Odile ; Cosson, Pierre

Oxford, UK: Oxford, UK : Blackwell Publishing Ltd

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