skip to main content
Idioma:

Induction Chemotherapy Followed by Cetuximab Radiotherapy Is Not Superior to Concurrent Chemoradiotherapy for Head and Neck Carcinomas: Results of the GORTEC 2007-02 Phase III Randomized Trial

Geoffrois, Lionnel ; Martin, Laurent ; De Raucourt, Dominique ; Sun, Xu Shan ; Tao, Yungan ; Maingon, Philippe ; Buffet, Joëlle ; Pointreau, Yoann ; Sire, Christian ; Tuchais, Claude ; Babin, Emmanuel ; Coutte, Alexandre ; Rolland, Frédéric ; Kaminsky, Marie-Christine ; Alfonsi, Marc ; Lapeyre, Michel ; Saliou, Marie ; Lafond, Cédric ; Jadaud, Eric ; Gery, Bernard ; Zawadi, Ayman ; Tourani, Jean-Marc ; Khoury, Cédric ; Henry, Anne Rose ; Hasbini, Ali ; Guichard, François ; Borel, Christian ; Meert, Nicolas ; Guillet, Pierre ; Calais, Marie-Hélène ; Garaud, Pascal ; Bourhis, Jean

Journal of clinical oncology, 2018-11, Vol.36 (31), p.3077-3083 [Periódico revisado por pares]

United States: American Society of Clinical Oncology

Texto completo disponível

Citações Citado por
  • Título:
    Induction Chemotherapy Followed by Cetuximab Radiotherapy Is Not Superior to Concurrent Chemoradiotherapy for Head and Neck Carcinomas: Results of the GORTEC 2007-02 Phase III Randomized Trial
  • Autor: Geoffrois, Lionnel ; Martin, Laurent ; De Raucourt, Dominique ; Sun, Xu Shan ; Tao, Yungan ; Maingon, Philippe ; Buffet, Joëlle ; Pointreau, Yoann ; Sire, Christian ; Tuchais, Claude ; Babin, Emmanuel ; Coutte, Alexandre ; Rolland, Frédéric ; Kaminsky, Marie-Christine ; Alfonsi, Marc ; Lapeyre, Michel ; Saliou, Marie ; Lafond, Cédric ; Jadaud, Eric ; Gery, Bernard ; Zawadi, Ayman ; Tourani, Jean-Marc ; Khoury, Cédric ; Henry, Anne Rose ; Hasbini, Ali ; Guichard, François ; Borel, Christian ; Meert, Nicolas ; Guillet, Pierre ; Calais, Marie-Hélène ; Garaud, Pascal ; Bourhis, Jean
  • Assuntos: Life Sciences
  • É parte de: Journal of clinical oncology, 2018-11, Vol.36 (31), p.3077-3083
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Both concurrent chemoradiotherapy (CT-RT) and cetuximab radiotherapy (cetux-RT) have been established as the standard of care for the treatment of locally advanced squamous cell carcinoma of the head and neck. It was not known whether the addition of induction chemotherapy before cetux-RT could improve outcomes compared with standard of care CT-RT. The current trial was restricted to patients with nonmetastatic N2b, N2c, or N3 squamous cell carcinoma of the head and neck and fit for taxotere, cisplatin, fluorouracil (TPF). Patients were randomly assigned to receive three cycles of TPF followed by cetux-RT versus concurrent carboplatin fluorouracil and RT as recommended in National Comprehensive Cancer Network guidelines. The trial was powered to detect a hazard ratio (HR) of 0.66 in favor of TPF plus cetux-RT for progression-free survival at 2 years. The inclusion of 180 patients per arm was needed to achieve 80% power at a two-sided significance level of .05. Between 2009 and 2013, 370 patients were included. All patients and tumors characteristics were well balanced between arms. There were more cases of grade 3 and 4 neutropenia in the induction arm, and the induction TPF was associated with 6.6% treatment-related deaths. With a median follow-up of 2.8 years, 2-year progression-free survival was not different between both arms (CT-RT, 0.38 TPF + cetux-RT, 0.36; HR, 0.93 [95% CI, 0.73 to 1.20]; = .58). HR was 0.98 (95% CI, 0.74 to 1.3; = .90) for locoregional control and 1.12 (95% CI, 0.86 to 1.46; = .39) for overall survival. These effects were observed regardless of p16 status. The rate of distant metastases was lower in the TPF arm (HR, 0.54 [95% CI, 0.30 to 0.99]; = .05). Induction TPF followed by cetux-RT did not improve outcomes compared with CT-RT in a population of patients with advanced cervical lymphadenopathy.
  • Editor: United States: American Society of Clinical Oncology
  • Idioma: Inglês
Links
Voltar para lista de resultados
Ir para página anteriorAnterior Resultado  6 AvançarIr para próxima página

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.