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Piroxicam and meloxicam ameliorate hepatic oxidative stress and protein carbonylation in Kupffer and sinusoidal endothelial cells promoted by ischemia–reperfusion injury

Montalvo‐Javé, Eduardo E. ; Ortega‐Salgado, José A. ; Castell, Andrés ; Carrasco‐Daza, Daniel ; Jay, David ; Gleason, Roberto ; Muñoz, Eduardo ; Montalvo‐Arenas, César ; Hernández‐Muñoz, Rolando ; Piña, Enrique

Transplant international, 2011-05, Vol.24 (5), p.489-500 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
Piroxicam and meloxicam ameliorate hepatic oxidative stress and protein carbonylation in Kupffer and sinusoidal endothelial cells promoted by ischemia–reperfusion injury
Autor: Montalvo‐Javé, Eduardo E. ; Ortega‐Salgado, José A. ; Castell, Andrés ; Carrasco‐Daza, Daniel ; Jay, David ; Gleason, Roberto ; Muñoz, Eduardo ; Montalvo‐Arenas, César ; Hernández‐Muñoz, Rolando ; Piña, Enrique
Assuntos: Alanine Transaminase - metabolism ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Aspartate Aminotransferases - metabolism ; Carbon - chemistry ; electron paramagnetic resonance ; Endothelial Cells - cytology ; Humans ; Ischemia ; ischemia–reperfusion injury ; Kupffer cells ; Kupffer Cells - metabolism ; L-Lactate Dehydrogenase - metabolism ; liver ; Liver - metabolism ; Nonsteroidal anti-inflammatory drugs ; Ornithine Carbamoyltransferase - metabolism ; Oxidative Stress ; Piroxicam - pharmacology ; protein carbonylation ; Proteins - metabolism ; Rats ; Rats, Wistar ; reactive oxygen species ; Reperfusion Injury ; Rodents ; sinusoidal endothelial cells ; Thiazines - pharmacology ; Thiazoles - pharmacology
É parte de: Transplant international, 2011-05, Vol.24 (5), p.489-500
Notas: Conflicts of Interest
The authors have declared no conflicts of interest.
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Descrição: Summary The present study was aimed to assess the effect of protein carbonylation (PC) in hepatic cells and effects of nonsteroidal anti‐inflammatory drugs (NSAIDs) on indicators of tissue damage induced by liver ischemia–reperfusion injury (LIRI). Warm ischemia was performed by partial vascular occlusion during 90 min in Wistar rats. In serum, we determined the catalytic activity of Alanine Aminotransferase, Aspartate Aminotransferase, Lacticate Dehydrogenase, and Ornithine Carbamoyltransferase. In liver samples, we studied cellular alterations by means of histologic studies, lipid peroxidation, PC by immunohistochemistry, apoptosis and reactive oxygen species in bile by electron paramagnetic resonance. Based on PC data, sinusoidal endothelial cells (SEC) and Kupffer cells (KC) were the first to exhibit LIRI‐associated oxidative damage and prior to parenchymal cells. Administration of piroxicam or meloxicam during the pre‐ischemic period produced a highly significant decrease in all studied injury indicators. No significant differences were revealed between the protective action of the two drugs. The data shown here suggest the potential use of NSAIDs such as piroxicam or meloxicam in minimizing ischemic event‐caused damage in liver. We also propose that PC may be employed as an adequate tool to assess tissue damage after oxidative stress.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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Piroxicam and meloxicam ameliorate hepatic oxidative stress and protein carbonylation in Kupffer and sinusoidal endothelial cells promoted by ischemia–reperfusion injury

Montalvo‐Javé, Eduardo E. ; Ortega‐Salgado, José A. ; Castell, Andrés ; Carrasco‐Daza, Daniel ; Jay, David ; Gleason, Roberto ; Muñoz, Eduardo ; Montalvo‐Arenas, César ; Hernández‐Muñoz, Rolando ; Piña, Enrique

Oxford, UK: Blackwell Publishing Ltd

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